Formation of C-strand Okazaki fragments

Stable Identifier
R-HSA-174444
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After RFC initiates the assembly of the primer recognition complex, the complex of pol delta and PCNA is responsible for incorporating the additional nucleotides prior to the position of the next downstream initiator RNA primer. On the lagging strand, short discontinuous segments of DNA, called Okazaki fragments, are synthesized on RNA primers. The average length of the Okazaki fragments is 100 nucleotides. Polymerase switching is a key event that allows the processive synthesis of DNA by the pol delta and PCNA complex.

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Event Information
Catalyst Activity
Catalyst Activity
Title
DNA-directed DNA polymerase activity of DNA Polymerase delta tetramer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created