The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere

Stable Identifier
R-HSA-174427
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
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The complementary strand is synthesized by the polymerase primase complex using conventional RNA priming (Dai et al. 2010).

Literature References
PubMed ID Title Journal Year
20639858 Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection

Dai, X, Huang, C, Bhusari, A, Sampathi, S, Schubert, K, Chai, W

EMBO J. 2010
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Catalyst Activity
Catalyst Activity
Title
DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
Physical Entity
DNA polymerase alpha:primase [nucleoplasm]
Activity
DNA-directed DNA polymerase activity (0003887)
Orthologous Events
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Caenorhabditis elegans)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Danio rerio)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Dictyostelium discoideum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Drosophila melanogaster)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Plasmodium falciparum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Saccharomyces cerevisiae)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Schizosaccharomyces pombe)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Xenopus tropicalis)
Authored
Blackburn, EH  (2006-03-10)
Seidel, J  (2006-03-10)
Reviewed
Price, C  (2006-07-13)
Created
Gillespie, ME  (2006-02-17)