SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen

Stable Identifier
R-HSA-174368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen
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The UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1) in hexameric form transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytosol into the ER lumen across the ER membrane (Muraoka et al. 2001). These substrates participate in glucuronidation and/or chondroitin sulfate biosynthesis.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

UDP-glucuronate transmembrane transporter activity of SLC35D1 hexamer [endoplasmic reticulum membrane]

Physical Entity
SLC35D1 hexamer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
UDP-glucuronate transmembrane transporter activity (GO:0005461)
Orthologous Events
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)
SLC35D2 exchanges UDP-GlcA for UMP (Homo sapiens)
Cross References
Rhea
Authored
Jassal, B  (2006-02-17)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-17)
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