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PSMB10 [nucleoplasm]
Stable Identifier
R-HSA-174349
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 10, Proteasome subunit beta type 10 precursor , Proteasome MECl-1, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB10 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40306 PSMB10
Gene Names
PSMB10, LMP10, MECL1
Chain
propeptide:1-39, chain:40-273
Reference Genes
BioGPS Gene:5699 PSMB10
COSMIC (genes):PSMB10 PSMB10
CTD Gene:5699 PSMB10
dbSNP Gene:5699 PSMB10
ENSEMBL:ENSG00000205220.12 PSMB10
HGNC:9538 PSMB10
KEGG Gene (Homo sapiens):5699 PSMB10
Monarch:5699 PSMB10
NCBI Gene:5699 PSMB10
OMIM:176847 PSMB10
UCSC:P40306 PSMB10
Reference Transcript
RefSeq:NM_002801.3 PSMB10
Other Identifiers
0005910138
11716640_a_at
11716641_x_at
11753939_x_at
16827483
202659_PM_at
202659_at
3696017
3696018
3696019
3696020
3696023
3696025
3696027
3696029
3696031
3696033
3696034
384_at
5699
8002133
A_33_P3288359
GE61663
GO:0000502
GO:0000902
GO:0002376
GO:0004175
GO:0004298
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006508
GO:0006959
GO:0008233
GO:0010498
GO:0016787
GO:0019774
GO:0030163
GO:0032991
GO:0042098
GO:0043226
GO:0048856
GO:0051603
GO:0140096
GO:1990111
HMNXSV003006497
ILMN_1683026
PH_hs_0000997
TC16002086.hg
X71874_cds1_at
g4506190_3p_s_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB10 [cytosol]
Inferred To
Ghost homologue of PSMB10 [nucleoplasm]
(Gallus gallus)
Ghost homologue of PSMB10 [nucleoplasm]
(Xenopus tropicalis)
Prosbeta2R1 [nucleoplasm]
(Drosophila melanogaster)
Prosbeta2 [nucleoplasm]
(Drosophila melanogaster)
Homologues of PSMB10 [nucleoplasm]
(Drosophila melanogaster)
PSMB10 [nucleoplasm]
(Bos taurus)
PSMB10 [nucleoplasm]
(Canis familiaris)
PSMB10 [nucleoplasm]
(Danio rerio)
PSMB10 [nucleoplasm]
(Sus scrofa)
Prosbeta2R2 [nucleoplasm]
(Drosophila melanogaster)
psmB7 [nucleoplasm]
(Dictyostelium discoideum)
Proteasome subunit beta type-10 [nucleoplasm]
(Mus musculus)
Psmb10 [nucleoplasm]
(Rattus norvegicus)
pbs-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002792.1
OpenTargets
ENSG00000205220
HPA
ENSG00000205220-PSMB10
ZINC - Substances
PSB10_HUMAN
GeneCards
P40306
ZINC target
P40306
Ensembl
ENST00000358514
,
ENSP00000351314
,
ENSG00000205220
PRO
P40306
Pharos - Targets
P40306
ZINC - Predictions - Purchasable
PSB10_HUMAN
PDB
6HV3
,
7B12
,
6HV4
,
7AWE
,
6AVO
,
6HVU
,
6E5B
,
6HVA
,
6HVT
,
6HV7
,
6HV5
,
6HVR
,
6HVW
,
6HVS
,
6HVV
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