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PSMB9 [nucleoplasm]
Stable Identifier
R-HSA-174334
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 9, Proteasome subunit beta type 9 precursor , Proteasome chain 7, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, RING12 protein, Low molecular mass protein 2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB9 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28065 PSMB9
Gene Names
PSMB9, LMP2, PSMB6i, RING12
Chain
propeptide:1-20, chain:21-219
Reference Genes
BioGPS Gene:5698 PSMB9
COSMIC (genes):PSMB9 PSMB9
CTD Gene:5698 PSMB9
dbSNP Gene:5698 PSMB9
ENSEMBL:ENSG00000240065 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000239836.7 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000240065.8 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000240118.7 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000240508.7 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000242711.8 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000243067.7 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000243594.7 PSMB9
ENSEMBL_homo_sapiens_GENE:ENSG00000243958.7 PSMB9
HGNC:9546 PSMB9
KEGG Gene (Homo sapiens):5698 PSMB9
Monarch:5698 PSMB9
NCBI Gene:5698 PSMB9
OMIM:177045 PSMB9
UCSC:P28065 PSMB9
Reference Transcript
RefSeq:NM_002800.4 PSMB9
Other Identifiers
11726677_a_at
11735623_a_at
17007307
204279_PM_at
204279_at
2903298
2903306
2903308
2903310
2903311
2903313
2903314
2903315
38287_at
5698
8118571
8178211
8179495
A_23_P111000
GE60353
GO:0000502
GO:0002376
GO:0003824
GO:0004175
GO:0004298
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006508
GO:0008233
GO:0010498
GO:0016787
GO:0019774
GO:0030163
GO:0043226
GO:0051603
GO:0070062
GO:0140096
GO:1990111
GO:2000116
HMNXSV003054514
ILMN_1798233
ILMN_2376108
PH_hs_0018571
PH_hs_0033030
TC6_apd_hap1000122.hg
TC6_cox_hap2000259.hg
X66401_cds1_at
g4506204_3p_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB9 [cytosol]
Inferred To
psmB6 [nucleoplasm]
(Dictyostelium discoideum)
Prosbeta1 [nucleoplasm]
(Drosophila melanogaster)
pbs-1 [nucleoplasm]
(Caenorhabditis elegans)
Psmb9 [nucleoplasm]
(Mus musculus)
Psmb9 [nucleoplasm]
(Rattus norvegicus)
PSMB9 [nucleoplasm]
(Bos taurus)
PSMB9 [nucleoplasm]
(Canis familiaris)
PSMB9 [nucleoplasm]
(Sus scrofa)
Ghost homologue of PSMB9 [nucleoplasm]
(Gallus gallus)
psmb9a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_002791.1
Guide to Pharmacology - Targets
2409
OpenTargets
ENSG00000240065
ZINC - Substances
PSB9_HUMAN
ZINC target
P28065
PRO
P28065
PDB
6AVO
,
7AWE
,
7B12
,
6E5B
GeneCards
P28065
HPA
ENSG00000240065-PSMB9
Ensembl
ENST00000444284
,
ENSP00000407233
,
ENST00000383234
,
ENST00000427870
,
ENSP00000363993
,
ENSP00000412027
,
ENSG00000240508
,
ENST00000453059
,
ENST00000374859
,
ENSP00000372721
,
ENSG00000240118
,
ENSP00000372595
,
ENST00000422729
,
ENSG00000240065
,
ENSP00000396813
,
ENSG00000243958
,
ENSP00000407810
,
ENSG00000243594
,
ENST00000434471
,
ENSG00000242711
,
ENSG00000243067
,
ENST00000383114
,
ENSG00000239836
,
ENSP00000393744
Pharos - Targets
P28065
ZINC - Predictions - Purchasable
PSB9_HUMAN
Orphanet
24831
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UL46 PSME2
2
PSME2 [cytosol]
(R-HSA-68814)
PSME2 [nucleoplasm]
(R-HSA-174350)
0.643
5
UniProt:Q9Y6Q9 NCOA3
2
NCOA3 [nucleoplasm]
(R-HSA-442488)
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
0.581
3
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.581
3
UniProt:Q9P0P0 RNF181
1
RNF181 [cytoplasm]
(R-HSA-8939317)
0.527
3
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.527
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.527
4
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