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PSMD4 [nucleoplasm]
Stable Identifier
R-HSA-174330
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit S5A, Rpn10, Multiubiquitin chain binding protein, Antisecretory factor-1, AF, ASF
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55036 PSMD4
Gene Names
PSMD4, MCB1
Chain
chain:1-377
Reference Genes
BioGPS Gene:5710 PSMD4
COSMIC (genes):PSMD4 PSMD4
CTD Gene:5710 PSMD4
dbSNP Gene:5710 PSMD4
ENSEMBL:ENSG00000159352 PSMD4
HGNC:9561 PSMD4
KEGG Gene (Homo sapiens):5710 PSMD4
Monarch:5710 PSMD4
NCBI Gene:5710 PSMD4
OMIM:601648 PSMD4
UCSC:P55036 PSMD4
Reference Transcript
RefSeq:NM_002810.2 PSMD4
Other Identifiers
0001660133
11757699_x_at
200882_3p_s_at
200882_s_at
210460_s_at
211609_x_at
2358822
2358826
2358827
2358832
2358833
2358835
2358837
2358838
2358842
2358844
2358849
2358850
3300871
3300872
3300876
3300877
3930994
3930995
39749_at
5710
7905374
A_23_P12168
GE554910
GE61019
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0010972
GO:0016579
GO:0022607
GO:0022624
GO:0030154
GO:0031145
GO:0031146
GO:0031593
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0036388
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043226
GO:0043248
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
HMNXSV003019851
HMNXSV003055643
ILMN_1728355
ILMN_2344130
ILMN_3307799
TC01001205.hg
U24704_at
g5292160_3p_at
g8918352_3p_s_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMD4 [cytosol]
Inferred To
psmD4 [nucleoplasm]
(Dictyostelium discoideum)
Psmd4 [nucleoplasm]
(Mus musculus)
Psmd4 [nucleoplasm]
(Rattus norvegicus)
psmd4a [nucleoplasm]
(Danio rerio)
rpn-10 [nucleoplasm]
(Caenorhabditis elegans)
PSMD4 [nucleoplasm]
(Canis familiaris)
PSMD4 [nucleoplasm]
(Sus scrofa)
rpn10 [nucleoplasm]
(Schizosaccharomyces pombe)
Rpn10 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002801.1
OpenTargets
ENSG00000159352
GeneCards
P55036
HPA
ENSG00000159352-PSMD4
Ensembl
ENSP00000357879
,
ENST00000368884
,
ENSG00000159352
PRO
P55036
Pharos - Targets
P55036
GlyGen
P55036
PDB
2KDE
,
1YX4
,
1P9D
,
1P9C
,
1YX6
,
1UEL
,
1YX5
,
5L4K
,
2KDF
,
5VHS
,
6MSK
,
6MUN
,
6WJN
,
5VHH
,
6MSH
,
6WJD
,
5VFT
,
5GJQ
,
5VHI
,
5GJR
,
6MSJ
,
5VFU
,
5VHF
,
5T0I
,
5VFR
,
5T0J
,
5VFS
,
6MSG
,
5T0G
,
5VFP
,
6MSD
,
5T0H
,
6MSE
,
5VFQ
,
5T0C
,
6U19
,
5M32
,
5LN3
,
5VGZ
,
6MSB
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.851
7
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.77
5
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.669
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P24610
1
Pax3 [nucleoplasm]
(R-MMU-5603237)
0.499
3
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.463
2
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