Reactome | PSME3 [nucleoplasm]

PSME3 [nucleoplasm]

Stable Identifier

R-HSA-174310

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome activator complex subunit 3, Proteasome activator 28-gamma subunit, PA28gamma, PA28g, Activator of multicatalytic protease subunit 3, 11S regulator complex gamma subunit, REG-gamma, Ki nuclear autoantigen

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSME3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61289 PSME3

Gene Names

PSME3

Chain

initiator methionine:, chain:2-254

Reference Genes

BioGPS Gene:10197 PSME3

COSMIC (genes):PSME3 PSME3

CTD Gene:10197 PSME3

dbSNP Gene:10197 PSME3

ENSEMBL:ENSG00000131467 PSME3

ENSEMBL_homo_sapiens_GENE:ENSG00000131467.12 PSME3

HGNC:9570 PSME3

KEGG Gene (Homo sapiens):10197 PSME3

Monarch:10197 PSME3

NCBI Gene:10197 PSME3

OMIM:605129 PSME3

UCSC:P61289 PSME3

Reference Transcript

Other Identifiers

10197

11729131_a_at

11729132_a_at

11756207_s_at

16834486

200987_PM_x_at

200987_x_at

200988_PM_s_at

200988_s_at

209852_PM_x_at

209852_x_at

209853_PM_s_at

209853_s_at

3722156

3722157

3722158

3722159

3722160

3722162

3722163

3722164

3722165

3722166

3722167

3722168

3722170

3722171

3722172

3722173

3722174

3722175

3722177

3722178

3722179

3722180

3722181

3722183

3722184

3722185

3722186

3722187

39796_at

8007397

A_23_P164141

A_24_P344307

GE61895

GO:0000278

GO:0000502

GO:0002039

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0007049

GO:0008537

GO:0012501

GO:0016020

GO:0023052

GO:0030163

GO:0042802

GO:0043226

GO:0061133

GO:0061136

GO:0097371

GO:0098772

GO:2000045

GO:2001237

HMNXSV003037526

Hs.152978.0.A1_3p_a_at

ILMN_1800975

ILMN_2346573

PH_hs_0009198

TC17000538.hg

U11292_at

g12655138_3p_a_at

g12803696_3p_a_at

g5031996_3p_a_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSME3 [cytosol]

Inferred To

PSME3 [nucleoplasm] (Gallus gallus)

PSME3 [nucleoplasm] (Sus scrofa)

psme3 [nucleoplasm] (Danio rerio)

Ghost homologue of PSME3 [nucleoplasm] (Bos taurus)

Ghost homologue of PSME3 [nucleoplasm] (Canis familiaris)

Ghost homologue of PSME3 [nucleoplasm] (Rattus norvegicus)

Psme3 [nucleoplasm] (Mus musculus)

psmE3 [nucleoplasm] (Dictyostelium discoideum)

REG [nucleoplasm] (Drosophila melanogaster)

psme-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_789839.1, NP_005780.2

OpenTargets

ENSG00000131467

GeneCards

P61289

HPA

ENSG00000131467-PSME3

Ensembl

ENSP00000409487, ENSG00000131467, ENST00000293362, ENST00000441946, ENSP00000466794, ENST00000590720, ENSP00000293362

PRO

P61289

Pharos - Targets

P61289

PDB

7YQD, 7YQC

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.841	9
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.781	7
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.621	3
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.612	8
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.602	5
UniProt:Q9HCE7 SMURF1	2	SMURF1 [cytosol] (R-HSA-975972) SMURF1 [nucleoplasm] (R-HSA-3004548)	0.593	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.576	7
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.564	3
UniProt:P42677 RPS27	2	RPS27 [nucleoplasm] (R-HSA-6791190) RPS27 [cytosol] (R-HSA-72361)	0.556	3
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.544	3
UniProt:Q8WY54 PPM1E	1	PPM1E [nucleoplasm] (R-HSA-9619432)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	3
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.527	2

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