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AURKA [cytosol]
Stable Identifier
R-HSA-174254
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aurora A
Locations in the PathwayBrowser for interactor UniProt:P42566 EPS15
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
SCF:FBXL7 binds AURKA (Homo sapiens)
AURKA [cytosol] (Homo sapiens)
Interaction between PHLDA1 and AURKA (Homo sapiens)
AURKA phosphorylates PHLDA1 (Homo sapiens)
AURKA [cytosol] (Homo sapiens)
PHLDA1 binds AURKA (Homo sapiens)
AURKA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14965 AURKA
Gene Names
AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Chain
chain:1-403
Reference Genes
BioGPS Gene:6790 AURKA
COSMIC (genes):AURKA AURKA
CTD Gene:6790 AURKA
dbSNP Gene:6790 AURKA
ENSEMBL:ENSG00000087586 AURKA
ENSEMBL_homo_sapiens_GENE:ENSG00000087586.18 AURKA
HGNC:11393 AURKA
KEGG Gene (Homo sapiens):6790 AURKA
Monarch:6790 AURKA
NCBI Gene:6790 AURKA
OMIM:603072 AURKA
UCSC:O14965 AURKA
Reference Transcript
RefSeq:NM_198434.2 AURKA
RefSeq:NM_001323303.1 AURKA
RefSeq:NM_198435.2 AURKA
RefSeq:XM_017028035.1 AURKA
RefSeq:NM_003600.3 AURKA
RefSeq:NM_198433.2 AURKA
RefSeq:NM_001323304.1 AURKA
RefSeq:NM_198436.2 AURKA
RefSeq:NM_001323305.1 AURKA
RefSeq:NM_198437.2 AURKA
Other Identifiers
11718943_a_at
11751206_s_at
16920548
204092_PM_s_at
204092_s_at
208079_PM_s_at
208079_s_at
2456937
2456940
2456941
2456943
2456944
3265227
3265230
34851_at
34852_g_at
3910786
3910787
3910788
3910789
3910790
3910791
3910796
3910797
3910800
3910802
3910803
3910804
3910805
3910806
3910807
3910808
6790
8067167
A_23_P131866
GE54110
GO:0000086
GO:0000166
GO:0000212
GO:0000226
GO:0000278
GO:0000776
GO:0000910
GO:0000922
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0005886
GO:0005929
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0007005
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007057
GO:0007059
GO:0007098
GO:0007100
GO:0009611
GO:0009948
GO:0010389
GO:0010629
GO:0012501
GO:0014069
GO:0015630
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0018105
GO:0019901
GO:0022414
GO:0023052
GO:0030030
GO:0030154
GO:0030163
GO:0030496
GO:0031616
GO:0031625
GO:0031647
GO:0032091
GO:0032133
GO:0032436
GO:0032465
GO:0035175
GO:0036064
GO:0036211
GO:0042585
GO:0042995
GO:0043005
GO:0043066
GO:0043161
GO:0043203
GO:0043226
GO:0044782
GO:0045120
GO:0045840
GO:0045931
GO:0046605
GO:0046777
GO:0046982
GO:0048471
GO:0048856
GO:0051233
GO:0051301
GO:0051321
GO:0051642
GO:0061523
GO:0071539
GO:0072686
GO:0072687
GO:0090141
GO:0097421
GO:0097431
GO:0098772
GO:0098978
GO:0106310
GO:0140013
GO:0140014
GO:0140096
GO:0140677
GO:1900195
GO:1901796
GO:1990138
HMNXSV003001259
ILMN_1680955
ILMN_2357438
PH_hs_0013285
TC20000968.hg
TC20001661.hg
g4507274_3p_s_at
Participates
as an input of
PHLDA1 binds AURKA (Homo sapiens)
SCF:FBXL7 binds AURKA (Homo sapiens)
as an output of
AURKA phosphorylates PHLDA1 (Homo sapiens)
as a component of
AURKA:PHLDA1 [cytosol] (Homo sapiens)
SCF-FBXL7:AURKA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
as a member of
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
Other forms of this molecule
SUMO1-K258-AURKA [cytosol]
p-T288-AURKA [nucleoplasm]
PolyUb-AURKA [cytosol]
AURKA [nucleoplasm]
p-T288-AURKA [cytosol]
Inferred To
AURKA [cytosol]
(Bos taurus)
AURKA [cytosol]
(Caenorhabditis elegans)
AURKA [cytosol]
(Canis familiaris)
AURKA [cytosol]
(Danio rerio)
AURKA [cytosol]
(Dictyostelium discoideum)
AURKA [cytosol]
(Drosophila melanogaster)
AURKA [cytosol]
(Gallus gallus)
AURKA [cytosol]
(Mus musculus)
AURKA [cytosol]
(Plasmodium falciparum)
AURKA [cytosol]
(Rattus norvegicus)
AURKA [cytosol]
(Saccharomyces cerevisiae)
AURKA [cytosol]
(Schizosaccharomyces pombe)
AURKA [cytosol]
(Sus scrofa)
AURKA [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_940835.1
,
NP_001310232.1
,
NP_940837.1
,
NP_001310234.1
,
NP_940839.1
,
NP_940836.1
,
XP_016883524.1
,
NP_001310233.1
,
NP_003591.2
,
NP_940838.1
ZINC - World Drugs
AURKA_HUMAN
Guide to Pharmacology - Targets
1936
OpenTargets
ENSG00000087586
ZINC - FDA approved
AURKA_HUMAN
ZINC - Substances
AURKA_HUMAN
ZINC target
O14965
ZINC - Biogenic
AURKA_HUMAN
PRO
O14965
PDB
3UP7
,
3O51
,
5ODT
,
8JF4
,
4J8N
,
5DN3
,
5ORL
,
3W10
,
5ORN
,
3VAP
,
3H0Z
,
8C15
,
2X6D
,
5DR9
,
6HJJ
,
5ORS
,
4DEE
,
8SSO
,
5ONE
,
8C14
,
5ORT
,
5DT3
,
3MYG
,
4CEG
,
2BMC
,
4JBQ
,
3FDN
,
8C1G
,
2W1G
,
6GRA
,
5EW9
,
5ORR
,
3UO6
,
6C2R
,
2XNE
,
5AAE
,
3NRM
,
8C1F
,
3W16
,
3UOJ
,
5ORX
,
6C83
,
2NP8
,
3UOK
,
5ORY
,
4JAI
,
4JBP
,
4O0S
,
5ORW
,
5OS6
,
5ORV
,
3LAU
,
4O0U
,
5OS3
,
1MQ4
,
6R4C
,
6VPG
,
1OL7
,
5AAF
,
6R4B
,
5OS4
,
2J4Z
,
5AAG
,
2W1E
,
5DPV
,
2X81
,
3H10
,
3QBN
,
8OF5
,
4ZTR
,
6I2U
,
3UO5
,
4ZTQ
,
4DEB
,
5ZAN
,
4JAJ
,
8GUW
,
5L8L
,
4B0G
,
4UZD
,
6Z4Y
,
6VPM
,
4C3P
,
6CPF
,
4UYN
,
6CPG
,
5LXM
,
8C1M
,
5DR2
,
3P9J
,
4DHF
,
8C1D
,
7O2V
,
6XKA
,
2WTW
,
5OS5
,
5DT4
,
3R22
,
6HJK
,
3K5U
,
3UOH
,
8JMX
,
3W2C
,
3COH
,
4C3R
,
3UP2
,
4DED
,
5OBR
,
5DT0
,
7FIC
,
5OBJ
,
5OSF
,
3HA6
,
8SSP
,
3R21
,
3W18
,
5OS1
,
5OS2
,
2X6E
,
2C6D
,
3UOL
,
2XNG
,
5DNR
,
5ORZ
,
3EFW
,
2W1F
,
8C1K
,
5OS0
,
4JBO
,
4ZS0
,
2WTV
,
6VPL
,
8C1E
,
5DOS
,
5ORO
,
2C6E
,
5G15
,
6VPJ
,
5ORP
,
3H0Y
,
3UOD
,
2WQE
,
3O50
,
6CPE
,
6VPI
,
1OL5
,
5G1X
,
6R4D
,
2W1C
,
6VPH
,
4BYI
,
4BYJ
,
4ZTS
,
1OL6
,
8C1I
,
7ZTL
,
4J8M
,
4BN1
,
2J50
,
4UZH
,
5DRD
,
2W1D
,
8C1H
,
6R4A
,
2DWB
,
5OSE
,
6C2T
,
5L8K
,
8JG8
,
5OSD
,
6R49
,
4PRJ
,
7AYI
,
5DR6
,
3E5A
,
4O0W
,
7AYH
,
1MUO
,
2XRU
,
3UO4
,
5AAD
,
3M11
,
5L8J
,
3UNZ
,
4DEA
ZINC - Investigational
AURKA_HUMAN
ZINC - Metabolites
AURKA_HUMAN
GeneCards
O14965
HPA
ENSG00000087586-AURKA
Ensembl
ENST00000395914
,
ENST00000312783
,
ENSP00000321591
,
ENSP00000379247
,
ENSP00000379249
,
ENSP00000360407
,
ENSG00000087586
,
ENSP00000379250
,
ENSP00000379251
,
ENST00000371356
,
ENST00000395913
,
ENST00000395911
,
ENST00000395915
,
ENSP00000216911
,
ENST00000347343
Pharos - Targets
O14965
ZINC - Predictions - Purchasable
AURKA_HUMAN
HMDB Protein
HMDBP01317
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.887
10
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.834
12
UniProt:Q8TEP8 CEP192
1
CEP192 [cytosol]
(R-HSA-380319)
0.802
8
UniProt:Q6PGQ7 BORA
3
p-S252-BORA [cytosol]
(R-HSA-4086411)
p-S252,S497,T501-BORA [cytosol]
(R-HSA-3000330)
BORA [cytosol]
(R-HSA-2562607)
0.656
3
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.643
3
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.643
4
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.632
11
UniProt:Q8VDQ8
1
SIRT2 [cytosol]
(R-MMU-2161118)
0.599
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.581
4
UniProt:Q9NQS7-1 INCENP
0.558
2
ChEBI:83432 CD532
0.558
2
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.544
2
UniProt:P23468 PTPRD
1
PTPRD [plasma membrane]
(R-HSA-6797868)
0.544
2
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.527
2
UniProt:O75170 PP6R2
0.527
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.527
2
UniProt:O43379 WDR62
0.527
3
UniProt:Q96DU7 ITPKC
1
ITPKC [cytosol]
(R-HSA-2023850)
0.527
2
UniProt:Q9P1Z2 CACO1
0.527
3
UniProt:P08218 CEL2B
0.527
2
UniProt:Q99689 FEZ1
0.527
2
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.527
3
UniProt:O15496 PLA2G10
1
PLA2G10 [extracellular region]
(R-HSA-1498793)
0.527
2
UniProt:Q96K76 USP47
1
USP47 [nucleoplasm]
(R-HSA-5696961)
0.527
3
UniProt:Q9C0C2 TNKS1BP1
1
TNKS1BP1 [cytosol]
(R-HSA-430011)
0.527
3
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.527
2
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.527
3
UniProt:A4D1S0 KLRG2
0.527
2
UniProt:Q5H9R7 PPP6R3
2
PPP6R3 [cytosol]
(R-HSA-5685722)
PPP6R3 [nucleoplasm]
(R-HSA-9686574)
0.527
4
UniProt:Q9H7T9 AUNIP
0.527
2
UniProt:Q9UGP4 LIMD1
1
LIMD1 [cytosol]
(R-HSA-8932473)
0.527
2
UniProt:Q96RF0 SNX18
1
SNX18 [cytosol]
(R-HSA-8868038)
0.527
3
UniProt:P14314 PRKCSH
3
PRKCSH [endoplasmic reticulum lumen]
(R-HSA-532666)
p-PRKCSH [endoplasmic reticulum lumen]
(R-HSA-8956890)
PRKCSH [plasma membrane]
(R-HSA-879405)
0.527
2
UniProt:Q86XD5 FAM131B
2
FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802323)
FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802527)
0.527
2
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.527
3
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.527
3
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
3
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.527
2
UniProt:Q9BYW2 SETD2
1
SETD2 [nucleoplasm]
(R-HSA-1183220)
0.527
3
UniProt:Q9Y6A5 TACC3
1
TACC3 [cytosol]
(R-HSA-2160956)
0.527
2
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.527
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.525
4
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.525
2
UniProt:Q9NWT8 AURKAIP1
1
AURKAIP1 [mitochondrial inner membrane]
(R-HSA-5368203)
0.524
2
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.524
2
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.524
3
UniProt:Q96R06 SPAG5
0.508
3
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.499
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.489
3
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