Reactome | BTRC [cytosol]

BTRC [cytosol]

Stable Identifier

R-HSA-174237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beta-TrCP, F-box/WD repeat-containing protein 1A

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9NX09 DDIT4

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
        
        Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)
        
        BTRC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y297 BTRC

Gene Names

BTRC, BTRCP, FBW1A, FBXW1A

Chain

chain:1-605

Reference Genes

BioGPS Gene:8945 BTRC

COSMIC (genes):BTRC BTRC

CTD Gene:8945 BTRC

dbSNP Gene:8945 BTRC

ENSEMBL:ENSG00000166167 BTRC

HGNC:1144 BTRC

KEGG Gene (Homo sapiens):8945 BTRC

Monarch:8945 BTRC

NCBI Gene:8945 BTRC

OMIM:603482 BTRC

UCSC:Q9Y297 BTRC

Reference Transcript

Other Identifiers

0005390215

0006840253

11724359_a_at

11724360_s_at

11735281_a_at

11748638_a_at

16708468

1P22

204901_at

216091_s_at

224471_s_at

2P64

31156

3261166

3261167

3261182

3261190

3261196

3261213

3261214

3261216

3261217

3261221

3261222

3261223

3261224

3261225

3261227

3261228

3261229

3261230

3261232

3261233

3261234

3261235

3261236

3261237

3261238

3261239

32986

39303_at

39304_g_at

39305_at

45239_at

60838_at

6M90

6M91

6M92

6M93

6M94

7929958

8945

A0A0S2Z4P6

A_14_P116259

A_23_P35427

A_23_P46819

AAD08702

AAF04464

AAH27994

ADU87633

AF101784

AF129530

AK313353

AL133387

AL445463

AL627424

ALQ33909

B7Z3H4

BAG36155

BC027994

BTRC

BTRC-202

BTRC-204

CAA74572

CAB032986

CCDS7511

CCDS7512

CH471066

EAW49772

EAW49774

ENSG00000166167

ENSP00000359206

ENSP00000385339

ENST00000370187

ENST00000370187.7

ENST00000408038

ENST00000408038.6

EntrezGene:8945

EntrezGene:BTRC

g13623214_3p_s_at

GE56992

GE80024

GE86308

GO:0000086

GO:0000209

GO:0000278

GO:0000462

GO:0002223

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006464

GO:0006470

GO:0006511

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008013

GO:0008150

GO:0008283

GO:0009056

GO:0009058

GO:0016032

GO:0016055

GO:0016567

GO:0016874

GO:0019005

GO:0030163

GO:0031146

GO:0031648

GO:0032040

GO:0032991

GO:0033598

GO:0034388

GO:0034641

GO:0038061

GO:0038095

GO:0042254

GO:0042752

GO:0042753

GO:0043122

GO:0043161

GO:0043226

GO:0043433

GO:0043687

GO:0044403

GO:0045309

GO:0045862

GO:0045879

GO:0045892

GO:0045893

GO:0046983

GO:0048511

GO:0048856

GO:0050852

GO:0051403

GO:0051726

GO:0060444

GO:0060828

GO:0061136

GO:0061630

GO:0070498

GO:0071407

GO:1901990

GU727631

HGNC:1144

HPA031156

Hs.226434.0.S2_3p_at

Hs.226434.1.S1_3p_a_at

ILMN_1689438

ILMN_1815718

IPR001680

IPR001810

IPR015943

IPR017986

IPR019775

IPR020472

IPR021977

IPR036047

IPR036322

KU178451

MIM:603482

NM_003939

NM_033637

NP_003930

NP_378663

PF00400

PF12125

PF12937

PH_hs_0029448

PR00320

Q5T1W7

SM00256

SM00320

SM01028

TC10000738.hg

TC10002257.hg

UPI00000012B5

UPI000002AA00

XM_006718054

XM_017016871

XM_017016872

XM_017016873

XM_024448247

XP_006718117

XP_016872360

XP_016872361

XP_016872362

XP_024304015

XR_001747256

Y14153

Participant Of

hasComponent

input

output

BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins

hasMember

Other forms of this molecule

BTRC [nucleoplasm]

Inferred To

BTRC [cytosol] (Danio rerio)

BTRC [cytosol] (Dictyostelium discoideum)

BTRC [cytosol] (Plasmodium falciparum)

BTRC [cytosol] (Saccharomyces cerevisiae)

BTRC [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of BTRC [cytosol] (Bos taurus)

Ghost homologue of BTRC [cytosol] (Caenorhabditis elegans)

Ghost homologue of BTRC [cytosol] (Canis familiaris)

Ghost homologue of BTRC [cytosol] (Drosophila melanogaster)

Ghost homologue of BTRC [cytosol] (Gallus gallus)

Ghost homologue of BTRC [cytosol] (Mus musculus)

Ghost homologue of BTRC [cytosol] (Rattus norvegicus)

Ghost homologue of BTRC [cytosol] (Sus scrofa)

Ghost homologue of BTRC [cytosol] (Xenopus tropicalis)

Homologues of BTRC [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_003930.1, NP_378663.1

OpenTargets

ENSG00000166167

GeneCards

Q9Y297

PRO

Q9Y297

Orphanet

22260

PDB

6M90, 6M94, 6M92, 2P64, 6M91, 6M93, 1P22

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.954	20
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.926	8
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.921	19
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551)	0.908	8
UniProt:Q13127 REST	1	REST [nucleoplasm] (R-HSA-480506)	0.766	10
UniProt:Q9C026 TRIM9	1	TRIM9 [cytosol] (R-HSA-976054)	0.764	6
UniProt:O75410-7 TACC1			0.696	5
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.691	4
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.675	4
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) Ub-C93-CDC34 [cytosol] (R-HSA-8864170) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.667	3
UniProt:Q5D1E8 ZC12A			0.667	3
UniProt:Q9C026-5 TRIM9			0.666	4
UniProt:O75410 TACC1			0.666	4
UniProt:Q8WWW0 RASF5			0.666	4
UniProt:Q13651 IL10RA	3	p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841) p-Y446-IL10RA [plasma membrane] (R-HSA-6784810)	0.635	5
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.597	3
UniProt:P69700 VPU			0.593	3
UniProt:Q5JTC6 AMER1	5	AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.591	5
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.591	9
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.589	3
UniProt:P10070 GLI2	11	GLI2 [ciliary base] (R-HSA-5610361) GLI2 [ciliary tip] (R-HSA-5610363) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471) p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.576	4
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.564	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.564	2
UniProt:P25963 NFKBIA	10	p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA [cytosol] (R-HSA-168151) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929) SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935)	0.564	2
UniProt:Q8WWW0-2 RASSF5			0.556	3
UniProt:Q16621 NFE2	1	NFE2 [nucleoplasm] (R-HSA-1008221)	0.556	3
UniProt:Q02750 MAP2K1	7	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.556	3
UniProt:P46937 YAP1	7	p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.547	2
UniProt:Q62696 Dlg1	4	Dlg1 [plasma membrane] (R-RNO-9617427) DLG1 [cytosol] (R-RNO-416332) Dlg1 [endoplasmic reticulum membrane] (R-RNO-9610616) DLG1 [plasma membrane] (R-RNO-375977)	0.524	3
UniProt:P63209 SKP1			0.508	2
UniProt:Q3KP66 INAVA			0.499	2
UniProt:Q76N32 CEP68			0.499	2
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.499	2
UniProt:Q5HYW2 NHSL2			0.488	2
UniProt:Q9NQ86 TRIM36	1	TRIM36 [cytosol] (R-HSA-976029)	0.488	2
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.488	2
UniProt:Q9Y2T1 AXIN2	4	RibC-AXIN2 [cytosol] (R-HSA-3640842) AXIN2 [cytosol] (R-HSA-3640821) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.488	2
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.462	2
UniProt:P19838 NFKB1	8	p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.462	4