Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex

Stable Identifier
R-HSA-174195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 3 molecules of 'ubiquitin', and 1 molecule of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated cell cycle protein:APC/C:Cdh1 complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' (Rape et al.1996).
Literature References
PubMed ID Title Journal Year
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A, Bernis, C, Vigneron, S, Labbe, JC, Lorca, T

Oncogene 2005
16413484 The processivity of multiubiquitination by the APC determines the order of substrate degradation

Rape, M, Reddy, SK, Kirschner, MW

Cell 2006
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
ubiquitin-dependent protein catabolic process (0006511)
Catalyst Activity

ubiquitin-protein transferase activity of cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol]

Physical Entity
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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