Reactome | PTTG1 [cytosol]

PTTG1 [cytosol]

Stable Identifier

R-HSA-174190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Securin, Pituitary tumor-transforming gene 1 protein

Locations in the PathwayBrowser for interactor UniProt:P16885 PLCG2

Expand all

External Reference Information

External Reference

UniProt:O95997 PTTG1

Gene Names

PTTG1, EAP1, PTTG, TUTR1

Chain

initiator methionine:1, chain:2-202

Reference Genes

BioGPS Gene:9232 PTTG1

COSMIC (genes):PTTG1 PTTG1

CTD Gene:9232 PTTG1

dbSNP Gene:9232 PTTG1

ENSEMBL:ENSG00000164611 PTTG1

HGNC:9690 PTTG1

KEGG Gene (Homo sapiens):9232 PTTG1

Monarch:9232 PTTG1

NCBI Gene:9232 PTTG1

OMIM:604147 PTTG1

Reference Transcript

Other Identifiers

0001770592

11717521_x_at

203554_PM_x_at

203554_x_at

2838202

2838203

2838204

2838205

2838207

2838209

2838211

2838212

2838213

40412_at

8109639

9232

A_14_P126126

A_23_P7636

GE87669

GO:0000003

GO:0000278

GO:0003674

GO:0004869

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006950

GO:0006974

GO:0007049

GO:0007059

GO:0007283

GO:0008150

GO:0010951

GO:0017124

GO:0030234

GO:0034641

GO:0043226

GO:0045143

GO:0051276

GO:0051301

GO:0140014

GO:2000816

HMNXSV003055972

ILMN_1753196

ILMN_2042771

TC05000896.hg

g11038651_3p_x_at

Participates

as a component of

as an input of

as a member of

(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)

Other forms of this molecule

K11polyUb-PTTG1 [cytosol]

Inferred To

XB5905938 [cytosol] (Xenopus tropicalis)

Ghost homologue of PTTG1 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PTTG1 [cytosol] (Drosophila melanogaster)

PTTG2 [cytosol] (Gallus gallus)

Pttg1 [cytosol] (Mus musculus)

Pttg1 [cytosol] (Rattus norvegicus)

pttg1 [cytosol] (Danio rerio)

PTTG1 [cytosol] (Bos taurus)

PTTG1 [cytosol] (Canis familiaris)

PTTG1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001269312.1, NP_004210.1, NP_001269311.1

OpenTargets

ENSG00000164611

HPA

ENSG00000164611-PTTG1

GeneCards

O95997

Ensembl

ENSP00000377536, ENSP00000344936, ENST00000520452, ENST00000352433, ENSG00000164611, ENSP00000430642, ENST00000393964

PRO

O95997

Pharos - Targets

O95997

PDB

7NJ0, 7NJ1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.748	7
UniProt:P60330	4	Espl1 [cytosol] (R-MMU-2467768) Espl1 [cytosol] (R-MMU-2500272) Espl1 [cytosol] (R-MMU-2467767) Espl1 [cytosol] (R-MMU-1638167)	0.564	2
UniProt:Q16698 DECR1	1	DECR1 [mitochondrial matrix] (R-HSA-53523)	0.564	2
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.544	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2

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