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Degradation of multiubiquitinated Cyclin B
Stable Identifier
R-HSA-174157
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
Degradation of multiubiquitinated Cyclin B (Homo sapiens)
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Mulitubiquitinated Cyclin B is targeted for degradation by the 26S proteasome.
Literature References
PubMed ID
Title
Journal
Year
11285280
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
Peters, JM
,
Gannon, J
,
Geley, S
,
Kramer, E
,
Gieffers, C
,
Hunt, T
J Cell Biol
2001
Participants
Input
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
(Homo sapiens)
Output
CDC20:p-APC/C [cytosol]
(Homo sapiens)
p-T161-CDK1 [cytosol]
(Homo sapiens)
x 4
Ub [cytosol]
(Homo sapiens)
Participates
as an event of
APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
Orthologous Events
Degradation of multiubiquitinated Cyclin B (Bos taurus)
Degradation of multiubiquitinated Cyclin B (Canis familiaris)
Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
Degradation of multiubiquitinated Cyclin B (Gallus gallus)
Degradation of multiubiquitinated Cyclin B (Mus musculus)
Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)
Degradation of multiubiquitinated Cyclin B (Sus scrofa)
Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-02-17)
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