SCF-beta-TrCP mediated degradation of Emi1

Stable Identifier
R-HSA-174113
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SCF-beta-TrCP mediated degradation of Emi1
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Emi1 destruction in early mitosis requires the SCF beta-TrCP ubiquitin ligase complex. Binding of beta-TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as well as Cdk mediated phosphorylation. A two-step mechanism has been proposed in which the phosphorylation of Emi1 by Cdc2 occurs after the G2-M transition followed soon after by binding of beta-TrCP to the DSGxxS phosphorylation sites. Emi1 is then poly-ubiquitinated and degraded by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Reimann, JD, Loktev, A, Hsu, JY, Jackson, PK, Margottin-Goguet, F, Hsieh, HM

Dev Cell 2003
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Events
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as an event of
Event Information
Go Biological Process
regulation of mitotic cell cycle phase transition (1901990)
Orthologous Events
SCF-beta-TrCP mediated degradation of Emi1 (Bos taurus)
SCF-beta-TrCP mediated degradation of Emi1 (Canis familiaris)
SCF-beta-TrCP mediated degradation of Emi1 (Danio rerio)
SCF-beta-TrCP mediated degradation of Emi1 (Drosophila melanogaster)
SCF-beta-TrCP mediated degradation of Emi1 (Gallus gallus)
SCF-beta-TrCP mediated degradation of Emi1 (Mus musculus)
SCF-beta-TrCP mediated degradation of Emi1 (Rattus norvegicus)
SCF-beta-TrCP mediated degradation of Emi1 (Sus scrofa)
SCF-beta-TrCP mediated degradation of Emi1 (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Castro, A  (2006-01-26)
Lorca, T  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-02-17)
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