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Association of Emi1 with Cdh1
Stable Identifier
R-HSA-174097
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Emi1 with Cdh1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Emi1 promotes the accumulation of Cyclin A and entry into S phase by associating with and inhibiting the APC/C:Cdh1 complex at G1/S.
Literature References
PubMed ID
Title
Journal
Year
11988738
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
Reimann, JD
,
Lukas, J
,
Hsu, JY
,
Sorensen, CS
,
Jackson, PK
Nat Cell Biol
2002
Participants
Input
Cdh1 [nucleoplasm]
(Homo sapiens)
FBXO5 [nucleoplasm]
(Homo sapiens)
Output
Emi1:Cdh1 complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Orthologous Events
Association of Emi1 with Cdh1 (Bos taurus)
Association of Emi1 with Cdh1 (Canis familiaris)
Association of Emi1 with Cdh1 (Danio rerio)
Association of Emi1 with Cdh1 (Drosophila melanogaster)
Association of Emi1 with Cdh1 (Gallus gallus)
Association of Emi1 with Cdh1 (Mus musculus)
Association of Emi1 with Cdh1 (Rattus norvegicus)
Association of Emi1 with Cdh1 (Sus scrofa)
Association of Emi1 with Cdh1 (Xenopus tropicalis)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-02-17)
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