Reactome | Factor D cleaves C3(H2O)-bound Factor B

Factor D cleaves C3(H2O)-bound Factor B

Stable Identifier

R-HSA-173745

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Factor D, a constitutively active serine protease found in trace amounts in the blood, cleaves a specific Arg-Lys bond in the Factor B component of the soluble C3(H2O):Factor B complex, yielding C3(H2O):Factor Bb and an inactive polypeptide, Factor Ba (Fearon and Austin 1975; Lesavre and Muller-Eberhard 1978; Lesavre et al. 1979; Schreiber et al. 1978).

Literature References

PubMed ID	Title	Journal	Year
279011	Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins Schreiber, RD, Pangburn, MK, Muller-Eberhard, HJ, Lesavre, PH	Proc Natl Acad Sci U S A	1978
82604	Mechanism of action of factor D of the alternative complement pathway Muller-Eberhard, HJ, Lesavre, PH	J Exp Med	1978
809512	Initiation of C3 cleavage in the alternative complement pathway Fearon, DT, Austen, KF	J Immunol	1975