Factor D cleaves C3(H2O)-bound Factor B

Stable Identifier
R-HSA-173745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Factor D, a constitutively active serine protease found in trace amounts in the blood, cleaves a specific Arg-Lys bond in the Factor B component of the soluble C3(H2O):Factor B complex, yielding C3(H2O):Factor Bb and an inactive polypeptide, Factor Ba (Fearon and Austin 1975; Lesavre and Muller-Eberhard 1978; Lesavre et al. 1979; Schreiber et al. 1978).

Literature References
PubMed ID Title Journal Year
82604 Mechanism of action of factor D of the alternative complement pathway

Lesavre, PH, Muller-Eberhard, HJ

J Exp Med 1978
279011 Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins

Schreiber, RD, Pangburn, MK, Lesavre, PH, Muller-Eberhard, HJ

Proc Natl Acad Sci U S A 1978
809512 Initiation of C3 cleavage in the alternative complement pathway

Fearon, DT, Austen, KF

J Immunol 1975
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Complement factor D [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created