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CFB(26-764) [extracellular region]
Stable Identifier
R-HSA-173738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CFB, Complement Factor B
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
Factor B binds to C3(H2O) (Homo sapiens)
C3(H2O):CFB [extracellular region] (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
Factor B binds to surface-associated C3b (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)
C3(H2O):CFB [extracellular region] (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
CFB(26-764) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00751 CFB
Gene Names
CFB, BF, BFD
Chain
signal peptide:1-25, chain:26-764, chain:26-259, chain:260-764
Reference Genes
BioGPS Gene:629 CFB
COSMIC (genes):CFB CFB
CTD Gene:629 CFB
dbSNP Gene:629 CFB
ENSEMBL:ENSG00000239754 CFB
ENSEMBL:ENSG00000241253 CFB
ENSEMBL:ENSG00000241534 CFB
ENSEMBL:ENSG00000242335 CFB
ENSEMBL:ENSG00000243570 CFB
ENSEMBL:ENSG00000243649 CFB
HGNC:1037 CFB
KEGG:hsa:629 CFB
Monarch:629 CFB
NCBI Gene:629 CFB
OMIM:138470 CFB
UCSC:P00751 CFB
Reference Transcript
RefSeq:NM_001710.5 CFB
Other Identifiers
11717045_a_at
11733725_a_at
11744331_a_at
11749355_a_at
11761555_at
17006949
202357_3p_s_at
202357_PM_s_at
202357_s_at
211920_PM_at
211920_at
2902836
2902837
2902845
2902846
2902848
2902849
2902850
2902851
2902852
2902853
2902854
2902855
2902856
2902857
2902858
2902859
2902860
2902861
2902862
2902863
2902864
2902865
2902866
2902867
2902868
2902869
2902870
2902871
2902872
2902873
2902874
2902875
2902876
2902877
2902878
2902879
2902880
2902881
2902882
2902883
33374_at
35822_at
629
8118345
8178115
8179351
A_14_P116860
A_23_P156687
A_32_P162183
GE60490
GE62019
GO:0001848
GO:0002376
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006956
GO:0006957
GO:0006958
GO:0008236
GO:0009617
GO:0016787
GO:0043226
GO:0070062
GO:0072562
GO:0098542
GO:0140096
HMNXSV003050772
ILMN_1774287
L09708_at
L15702_at
PH_hs_0004112
TC06004077.hg
TC6_cox_hap2000245.hg
TC6_dbb_hap3000222.hg
TC6_mann_hap4000196.hg
TC6_mcf_hap5000213.hg
TC6_qbl_hap6000225.hg
TC6_ssto_hap7000199.hg
g13560704_3p_at
g4502396_3p_at
g4502396_3p_s_at
g4502396_3p_x_at
g4557382_3p_at
p33713
Participates
as an input of
Factor B binds to C3(H2O) (Homo sapiens)
Factor B binds to surface-associated C3b (Homo sapiens)
as a component of
C3(H2O):CFB [extracellular region] (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
Other forms of this molecule
CFB(260-764) [extracellular region]
CFB(260-764) [plasma membrane]
CFB(26-259) [extracellular region]
Inferred To
cfb [extracellular region]
(Xenopus tropicalis)
Cfb [extracellular region]
(Mus musculus)
cfbl [extracellular region]
(Danio rerio)
CFB [extracellular region]
(Bos taurus)
CFB [extracellular region]
(Canis familiaris)
CFB [extracellular region]
(Sus scrofa)
Homologues of CFB(26-764) [extracellular region]
(Danio rerio)
bfb [extracellular region]
(Danio rerio)
CFB(26-764) [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_001701.2
Guide to Pharmacology - Targets
2339
OpenTargets
ENSG00000243649
ENSEMBL
ENSP00000414889
,
ENST00000426239
,
ENSP00000416561
,
ENSP00000411474
,
ENSP00000382862
,
ENSP00000411515
,
ENST00000417261
,
ENST00000455591
,
ENSP00000391902
,
ENST00000427888
,
ENST00000425368
,
ENST00000436692
,
ENSP00000388352
,
ENST00000433503
,
ENSP00000414341
,
ENSP00000389604
,
ENSP00000413351
,
ENST00000424727
,
ENST00000399981
,
ENSP00000401719
,
ENST00000419920
,
ENST00000419411
ZINC - Substances
CFAB_HUMAN
ZINC target
P00751
PRO
P00751
GlyGen
P00751
PDB
1RRK
,
1RS0
,
1RTK
,
6QSW
,
2WIN
,
8ENU
,
6RAV
,
2OK5
,
8EOK
,
6RUR
,
7NOZ
,
2XWB
,
2XWJ
,
6RUV
,
6QSX
,
6T8V
,
3HS0
,
8UIN
,
6T8W
,
3HRZ
,
7JTQ
,
7JTN
,
1DLE
,
6T8U
,
1Q0P
HPA
ENSG00000243649-CFB
Pharos - Targets
P00751
Orphanet
CFB
ZINC - Predictions - Purchasable
CFAB_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.75
4
UniProt:Q92496-3 CFHR4
0.609
2
UniProt:Q91132 VCO3
0.57
3
UniProt:Q92496-1 CFHR4
0.544
2
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
UniProt:Q96DX4 RSPRY
0.527
3
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