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C9 binds C5b:C6:C7:C8
Stable Identifier
R-HSA-173725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
external side of plasma membrane
Synonyms
Creation of the Membrane Attack Complex (MAC)
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
C9 binds C5b:C6:C7:C8 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The membrane attack complex (MAC) is the cytolytic end product of the complement cascade, composed of one C5:C6:C7:C8 complex and 12 to 15 C9 molecules (Podack et al. 1982, Biesecker et al. 1993). 12 C9 molecules are represented in this reaction. C9 peptides polymerize to form a ring-shaped transmembrane channel, which causes osmotic lysis of the target cell (Kondos et al. 2010). While formation of a pore is typically associated with necrotic cell death, there is evidence of membrane permeabilization from MACs containing one C9 molecule per C5b–8 complex (Sims et al. 1983).
Literature References
PubMed ID
Title
Journal
Year
6177822
Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly
Tschoop, J
,
Podack, ER
,
Müller-Eberhard, HJ
J Exp Med
1982
Participants
Input
C5b:C6:C7:C8 [plasma membrane]
(Homo sapiens)
x 12
C9(22-559) [extracellular region]
(Homo sapiens)
Output
Membrane Attack Complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Terminal pathway of complement (Homo sapiens)
This event is regulated
Negatively by
Regulator
CLU:C5b:C6:C7, C8, C9 [extracellular region]
(Homo sapiens)
Orthologous Events
C9 binds C5b:C6:C7:C8 (Bos taurus)
C9 binds C5b:C6:C7:C8 (Canis familiaris)
C9 binds C5b:C6:C7:C8 (Mus musculus)
C9 binds C5b:C6:C7:C8 (Sus scrofa)
C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)
Authored
de Bono, B (2004-08-04)
Reviewed
D'Eustachio, P (2006-07-04)
Created
de Bono, B (2006-02-16)
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