C9 binds C5b:C6:C7:C8

Stable Identifier
R-HSA-173725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
external side of plasma membrane
Synonyms
Creation of the Membrane Attack Complex (MAC)
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C9 binds C5b:C6:C7:C8
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The membrane attack complex (MAC) is the cytolytic end product of the complement cascade, composed of one C5:C6:C7:C8 complex and 12 to 15 C9 molecules (Podack et al. 1982, Biesecker et al. 1993). 12 C9 molecules are represented in this reaction. C9 peptides polymerize to form a ring-shaped transmembrane channel, which causes osmotic lysis of the target cell (Kondos et al. 2010). While formation of a pore is typically associated with necrotic cell death, there is evidence of membrane permeabilization from MACs containing one C9 molecule per C5b–8 complex (Sims et al. 1983).

Literature References
PubMed ID Title Journal Year
6177822 Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly

Podack, ER, Tschoop, J, Müller-Eberhard, HJ

J Exp Med 1982
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This event is regulated
Negatively by
Orthologous Events
C9 binds C5b:C6:C7:C8 (Canis familiaris)
C9 binds C5b:C6:C7:C8 (Danio rerio)
C9 binds C5b:C6:C7:C8 (Mus musculus)
C9 binds C5b:C6:C7:C8 (Rattus norvegicus)
C9 binds C5b:C6:C7:C8 (Sus scrofa)
C9 binds C5b:C6:C7:C8 (Xenopus tropicalis)
C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)