C5b:C6:C7 translocates to the plasma membrane

Stable Identifier
R-HSA-173720
Type
Reaction [transition]
Species
Homo sapiens
Compartment
external side of plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
C5b:C6:C7 translocates to the plasma membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C7 recruitment of C7 results in a weak association of C5b:C6:C7 with the target cell membrane, through a poorly characterized molecular mechanism (Muller -Eberhard et al. 1986). C5b and C6 remains loosely bound to C3b until C5b binds to C7 and induces it to undergo a hydrophilic-amphiphilic transition. Hydrophobic binding regions for phospholipid are thereby exposed, and the trimolecular complex is endowed with a metastable membrane binding site. Membranebound C5b-7 inflicts no harm on a cell but marks it for further assault.

Literature References
PubMed ID Title Journal Year
3052276 Molecular organization and function of the complement system

Muller-Eberhard, HJ

Annu Rev Biochem 1988
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Orthologous Events
C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)
C5b:C6:C7 translocates to the plasma membrane (Danio rerio)
C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)
C5b:C6:C7 translocates to the plasma membrane (Mus musculus)
C5b:C6:C7 translocates to the plasma membrane (Rattus norvegicus)
C5b:C6:C7 translocates to the plasma membrane (Xenopus tropicalis)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)
Cite Us!