Reactome | C1QC [extracellular region]

C1QC

Stable Identifier

R-HSA-173563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Classical antibody-mediated complement activation (Homo sapiens)
        
        Activation of C1r (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Homo sapiens)
        
        C1Q:2xC1R:2xC1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        Activation of C1s (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
    - Regulation of Complement cascade (Homo sapiens)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
      - C1-Inh binds and inactivates C1r, C1s (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
        
        C1Q [extracellular region] (Homo sapiens)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Homo sapiens)
        
        C1QC [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02747 C1QC

Gene Names

C1QC, C1QG

Chain

signal peptide:1-28, chain:29-245

Reference Genes

BioGPS Gene:714 C1QC

COSMIC (genes):C1QC C1QC

CTD Gene:714 C1QC

dbSNP Gene:714 C1QC

ENSEMBL:ENSG00000159189 C1QC

HGNC:1245 C1QC

KEGG Gene (Homo sapiens):hsa:714 C1QC

Monarch:714 C1QC

NCBI Gene:714 C1QC

OMIM:120575 C1QC

UCSC:P02747 C1QC

Reference Transcript

Other Identifiers

0002970372

11720388_s_at

1471

16660581

1PK6

225353_s_at

2324874

2324875

2324876

2324877

2324878

2324879

2324880

2324881

2JG8

2JG9

2WNU

2WNV

46705_at

5HKJ

5HZF

6FCZ

714

7898799

9828

A0A024RAA7

A_23_P125977

AAH09016

AAP97191

AF087892

AK057792

AL158086

BAB71575

BC009016

C1QC

C1QC-201

C1QC-202

C1QC-203

CAB009828

CCDS227

CH471134

EAW95016

EAW95017

EAW95018

ENSG00000159189

ENSP00000363768

ENSP00000363770

ENSP00000363771

ENST00000374637

ENST00000374639

ENST00000374640

EntrezGene:714

GE79267

GO:0002376

GO:0003674

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005615

GO:0006508

GO:0006950

GO:0006955

GO:0006956

GO:0006958

GO:0008150

GO:0008233

GO:0030154

GO:0030449

GO:0030853

GO:0032991

GO:0045087

GO:0045650

GO:0048856

GO:0051604

GO:0072562

HGNC:1245

HPA001471

Hs.94953.0.A1_3p_a_at

ILMN_1785902

IPR001073

IPR008160

IPR008983

LRG_24

LRG_24t1

MIM:120575

MIM:613652

NM_001114101

NM_172369

NP_001107573

NP_001334548

NP_758957

PF00386

PF01391

PR00007

SM00110

TC01000286.hg

uc001bga.5

uc001bgc.5

uc057ddy.1

UPI0000126BF3

Participant Of

hasComponent

C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region]

Inferred To

C1QC [extracellular region] (Bos taurus)

C1QC [extracellular region] (Canis familiaris)

C1QC [extracellular region] (Danio rerio)

C1QC [extracellular region] (Gallus gallus)

C1QC [extracellular region] (Mus musculus)

C1QC [extracellular region] (Rattus norvegicus)

C1QC [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001334548.1, NP_001107573.1, NP_758957.2

GeneCards

P02747

PRO

P02747

Orphanet

18953

HMDB Protein

HMDBP07479

PDB

1PK6, 2JG9, 2WNV, 6FCZ, 5HKJ, 5HZF, 2WNU, 2JG8