Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Stable Identifier
R-HSA-173545
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
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The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.
Literature References
PubMed ID Title Journal Year
10587654 SMAD destruction turns off signalling

ten Dijke, P, Heldin, CH

Nat Cell Biol 1999
10587642 Ubiquitin-dependent degradation of TGF-beta-activated smad2

Massague, J, Lo, RS

Nat Cell Biol 1999
Participants
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]

Physical Entity
Nuclear ubiquitin ligase [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)
Authored
Jassal, B  (2006-02-02)
Huminiecki, L  (2006-02-02)
Moustakas, A  (2006-02-02)
Heldin, CH  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Heldin, CH  (2006-04-18)
Contreras, O  (2022-05-02)
Created
Jassal, B  (2006-02-14)
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