Reactome | SMURF2 [cytosol]

SMURF2 [cytosol]

Stable Identifier

R-HSA-173537

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:Q99717 SMAD5

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External Reference Information

External Reference

UniProt:Q9HAU4 SMURF2

Gene Names

SMURF2

Chain

chain:1-748

Reference Genes

BioGPS Gene:64750 SMURF2

COSMIC (genes):SMURF2 SMURF2

CTD Gene:64750 SMURF2

dbSNP Gene:64750 SMURF2

ENSEMBL:ENSG00000108854 SMURF2

HGNC:16809 SMURF2

KEGG Gene (Homo sapiens):64750 SMURF2

Monarch:64750 SMURF2

NCBI Gene:64750 SMURF2

OMIM:605532 SMURF2

UCSC:Q9HAU4 SMURF2

Reference Transcript

RefSeq:NM_022739.3 SMURF2

Other Identifiers

0003940048

11723820_a_at

11723821_a_at

11748382_a_at

16847841

17121638

205596_s_at

227489_at

232020_3p_at

232020_at

33354_at

3716598

3717021

3717022

3732647

3766961

3766962

3766963

3766965

3766968

3766972

3766973

3766974

3766975

3766976

3766977

3766979

3766983

3766986

3766989

3766991

3766997

3767002

3767006

3767008

3767026

3767027

3767028

4040318

4040630

58405_at

64750

65451_i_at

8017651

91240_at

A_23_P100754

A_24_P210888

A_33_P3370751

GE88328

GO:0000003

GO:0000122

GO:0000151

GO:0000209

GO:0003674

GO:0004842

GO:0005160

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0007165

GO:0007267

GO:0008150

GO:0009056

GO:0009058

GO:0016020

GO:0016567

GO:0016579

GO:0016607

GO:0016740

GO:0017015

GO:0030509

GO:0030512

GO:0030514

GO:0030579

GO:0032991

GO:0034641

GO:0040011

GO:0042802

GO:0043161

GO:0043226

GO:0045121

GO:0045732

GO:0045892

GO:0046332

GO:0048856

GO:0048870

GO:0060071

GO:0061630

GO:0090263

GO:1901165

Hs.169872.0.A1_3p_at

Hs.323849.0.S1_3p_x_at

ILMN_1675429

PH_hs_0025712

TC17001803.hg

g12408118_3p_at

Participant Of

hasComponent

hasMember

output

input

Other forms of this molecule

SMURF2 [nucleoplasm]

Inferred To

Smurf2 [cytosol] (Mus musculus)

Smurf2 [cytosol] (Rattus norvegicus)

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

Smurf [cytosol] (Drosophila melanogaster)

smurf2 [cytosol] (Danio rerio)

pub3 [cytosol] (Schizosaccharomyces pombe)

Homologues of SMURF2 [cytosol] (Dictyostelium discoideum)

Homologues of SMURF2 [cytosol] (Schizosaccharomyces pombe)

SMURF2 [cytosol] (Dictyostelium discoideum)

SMURF2 [cytosol] (Gallus gallus)

SMURF2 [cytosol] (Plasmodium falciparum)

SMURF2 [cytosol] (Sus scrofa)

pub2 [cytosol] (Schizosaccharomyces pombe)

ccdc47 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_073576.1

OpenTargets

ENSG00000108854

HPA

ENSG00000108854-SMURF2

GeneCards

Q9HAU4

Ensembl

ENSG00000108854, ENSP00000262435, ENST00000262435

PRO

Q9HAU4

HMDB Protein

HMDBP09306

PDB

1ZVD, 2KXQ, 2LTZ, 2DJY, 2JQZ, 6FX4

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15797 SMAD1	4	SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.811	6
UniProt:Q15796 SMAD2	27	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 Q429* [cytosol] (R-HSA-9668727) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 [nucleoplasm] (R-HSA-3006352) SMAD2 [cytosol] (R-HSA-3006353) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185)	0.811	6
UniProt:O15105 SMAD7	2	SMAD7 [cytosol] (R-HSA-173478) SMAD7 [nucleoplasm] (R-HSA-178197)	0.801	7
UniProt:P84022 SMAD3	21	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [nucleoplasm] (R-HSA-206150) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.799	8
UniProt:Q9Y3C5 RNF11			0.737	5
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.709	6
UniProt:P0CG47 UBB	109	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(153-228) [late endosome lumen] (R-HSA-9660014) UBB(77-152) [late endosome lumen] (R-HSA-9660021) UBB(1-76) [late endosome lumen] (R-HSA-9660017) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) UBB(77-152) [lysosomal lumen] (R-HSA-9660011) UBB(1-76) [lysosomal lumen] (R-HSA-9660024) UBB(153-228) [lysosomal lumen] (R-HSA-9660025) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.623	4
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.602	3
UniProt:P46934-4 NEDD4			0.59	2
UniProt:Q8WWV3 RT4I1			0.556	3
UniProt:Q99717 SMAD5	3	p-S463,S465-SMAD5 [nucleoplasm] (R-HSA-201432) SMAD5 [cytosol] (R-HSA-201431) p-S463,S465-SMAD5 [cytosol] (R-HSA-201473)	0.547	2
UniProt:Q9WMX2-PRO_0000037548			0.508	2

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