Reactome | LDL + LDLR => LDL:LDLR complex

LDL + LDLR => LDL:LDLR complex

Stable Identifier

R-HSA-171122

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Low density lipoprotein (LDL) particles associate with LDL receptors (LDLR) at the cell surface (Goldstein et al. 1979). This binding is mediated by the apoprotein B-100 component of the LDL particle, which binds LDLR with 1:1 stoichiometry (van Driel et al. 1989).

Literature References

PubMed ID	Title	Journal	Year
221835	Coated pits, coated vesicles, and receptor-mediated endocytosis Goldstein, JL, Anderson, RG, Brown, MS	Nature	1979
2722848	Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay Van Driel, IR, Brown, MS, Goldstein, JL	J Biol Chem	1989