LDLR:LDL complex => LDLR + LDL

Stable Identifier
R-HSA-171106
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endosome membrane, endosome lumen
Synonyms
Dissociation of the LDL:LDLR complex in the early endosome
ReviewStatus
5/5
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LDLR:LDL complex => LDLR + LDL
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Dissociation of the LDL:LDLR complex in the early endosome frees the LDL particle to be transferred to lysosomes for degradation while the LDL receptor is returned to the plasma membrane (Goldstein et al. 1979).
Literature References
PubMed ID Title Journal Year
221835 Coated pits, coated vesicles, and receptor-mediated endocytosis

Goldstein, JL, Brown, MS, Anderson, RG

Nature 1979
Participants
Input
Output
Participates
as an event of
Orthologous Events
chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)
LDLR:LDL complex => LDLR + LDL (Bos taurus)
LDLR:LDL complex => LDLR + LDL (Canis familiaris)
LDLR:LDL complex => LDLR + LDL (Mus musculus)
LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)
LDLR:LDL complex => LDLR + LDL (Sus scrofa)
Authored
D'Eustachio, P  (2007-04-30)
Created
D'Eustachio, P  (2006-01-28)
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