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LDL [endosome lumen]
Stable Identifier
R-HSA-171082
Type
Complex
Species
Homo sapiens
Compartment
endosome lumen
Synonyms
low-density lipoprotein complex
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
LDL [endosome lumen] (Homo sapiens)
LDLR:LDL complex => LDLR + LDL (Homo sapiens)
LDL [endosome lumen] (Homo sapiens)
General
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
Participants
components
APOB(28-4563) [endosome lumen]
(Homo sapiens)
x 670
cholesterol [endosome lumen]
x 1500
cholesterol esters [endosome lumen]
x 690
PL [endosome lumen]
x 170
TAGs [endosome lumen]
Participates
as an input of
LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
as an output of
LDLR:LDL complex => LDLR + LDL (Homo sapiens)
Inferred To
LDL [endosome lumen]
(Bos taurus)
LDL [endosome lumen]
(Canis familiaris)
LDL [endosome lumen]
(Gallus gallus)
LDL [endosome lumen]
(Mus musculus)
LDL [endosome lumen]
(Rattus norvegicus)
LDL [endosome lumen]
(Sus scrofa)
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