Reactome | Binding and activation of MAP Kinase

Binding and activation of MAP Kinase

Stable Identifier

R-HSA-171011

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Signalling to RAS (Homo sapiens)
        
        p38MAPK events (Homo sapiens)
        
        Binding and activation of MAP Kinase (Homo sapiens)

General

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The NGF activation of p38 MAP kinase is transient, being maximal at 10 min and declining to near control levels by 30 min. T180 and Y182 are two sites that become newly phosphorylated as p38 MAPK becomes activated.

Participants

Input

Output

Participant Of

hasEvent

p38MAPK events

Catalyst Activity

Title

protein tyrosine kinase activity of p-Y419-SRC-1 [plasma membrane]

Physical Entity

p-Y419-SRC-1 [plasma membrane]

Activity

protein tyrosine kinase activity (0004713)

Inferred From

Binding and activation of MAP kinase (Rattus norvegicus)

Authored

Nasi, S (2006-10-10)

Annibali, D (2006-10-10)

Reviewed

Greene, LA (2007-11-08)

Created

Jassal, B (2006-01-25)