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Binding and activation of MAP Kinase
Stable Identifier
R-HSA-171011
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
Binding and activation of MAP Kinase (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The NGF activation of p38 MAP kinase is transient, being maximal at 10 min and declining to near control levels by 30 min. T180 and Y182 are two sites that become newly phosphorylated as p38 MAPK becomes activated.
Participants
Input
x 2
ATP [cytosol]
MAP kinase p38 (Mg2+ cofactor) [cytosol]
(Homo sapiens)
Output
x 2
ADP [cytosol]
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]
(Homo sapiens)
Participates
as an event of
p38MAPK events (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of p-Y419-SRC-1 [plasma membrane]
Physical Entity
p-Y419-SRC-1 [plasma membrane]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Binding and activation of MAP kinase (Rattus norvegicus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-01-25)
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