FRS2 is phosphorylated by active TrkA receptor

Stable Identifier
R-HSA-170977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated TrkA induces the tyrosine phosphorylation of the lipid-anchored docking protein, FRS2. FRS2 is an adapter protein that links NGF receptors to downstream signaling pathways. It is involved in the activation of MAP kinases.

Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Active TrkA receptor:FRS2 complex [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created