FRS2 is phosphorylated by active TrkA receptor

Stable Identifier
R-HSA-170977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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FRS2 is phosphorylated by active TrkA receptor
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Activated TrkA induces the tyrosine phosphorylation of the lipid-anchored docking protein, FRS2. FRS2 is an adapter protein that links NGF receptors to downstream signaling pathways. It is involved in the activation of MAP kinases.
Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Active TrkA receptor:FRS2 complex [endosome membrane]

Physical Entity
Active TrkA receptor:FRS2 complex [endosome membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
FRS2 is phosphorylated by active TrkA receptor (Bos taurus)
FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)
FRS2 is phosphorylated by active TrkA receptor (Danio rerio)
FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)
FRS2 is phosphorylated by active TrkA receptor (Mus musculus)
FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)
FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)
FRS2 is phosphorylated by active TrkA receptor (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-01-25)
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