Activated type I receptor phosphorylates SMAD2/3 directly

Stable Identifier
R-HSA-170868
Type
Reaction
Species
Homo sapiens
Compartment
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Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD1, SMAD5 or SMAD8. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References
PubMed ID Title Journal Year
11100470 Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

Souchelnytskyi, S, ten Dijke, P, Heldin, CH, Rönnstrand, L

Methods Mol Biol 2001
Participants
Participates
Catalyst Activity

transmembrane receptor protein serine/threonine kinase activity of TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]

Orthologous Events
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