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TGFBR2 homodimer [plasma membrane]
Stable Identifier
R-HSA-170866
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Type II receptor complex
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)
Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Loss of Function of TGFBR1 in Cancer (Homo sapiens)
TGFBR1 KD Mutants in Cancer (Homo sapiens)
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 KD Mutants [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR1 LBD Mutants in Cancer (Homo sapiens)
TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Degradation of TGF-beta receptor complex (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 recruits TGFBR1 (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
SMURF1 ubiquitinates RHOA (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 regulates TGF-beta signaling (Homo sapiens)
TGFBR3 phosphorylation by TGFBR2 complex (Homo sapiens)
TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
TGFBR2 [plasma membrane]
(Homo sapiens)
Participates
as a component of
TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 KD Mutants [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:Smad7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [early endosome membrane] (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
Inferred To
TGFBR2 homodimer [plasma membrane]
(Bos taurus)
TGFBR2 homodimer [plasma membrane]
(Caenorhabditis elegans)
TGFBR2 homodimer [plasma membrane]
(Canis familiaris)
TGFBR2 homodimer [plasma membrane]
(Danio rerio)
TGFBR2 homodimer [plasma membrane]
(Drosophila melanogaster)
TGFBR2 homodimer [plasma membrane]
(Gallus gallus)
TGFBR2 homodimer [plasma membrane]
(Mus musculus)
TGFBR2 homodimer [plasma membrane]
(Rattus norvegicus)
TGFBR2 homodimer [plasma membrane]
(Sus scrofa)
TGFBR2 homodimer [plasma membrane]
(Xenopus tropicalis)
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