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TGFBR2 [plasma membrane]
Stable Identifier
R-HSA-170842
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TGF-beta II receptor
Icon
Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
CBL binds TGFBR2 (Homo sapiens)
TGFBR2 [plasma membrane] (Homo sapiens)
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
TGFBR2 [plasma membrane] (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 regulates TGF-beta signaling (Homo sapiens)
TGFBR3 complex binds to TGFBR2 (Homo sapiens)
TGFBR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P37173 TGFBR2
Gene Names
TGFBR2
Chain
signal peptide:1-22, chain:23-567
Reference Genes
BioGPS Gene:7048 TGFBR2
COSMIC (genes):TGFBR2 TGFBR2
CTD Gene:7048 TGFBR2
dbSNP Gene:7048 TGFBR2
ENSEMBL:ENSG00000163513 TGFBR2
ENSEMBL_homo_sapiens_GENE:ENSG00000163513.19 TGFBR2
HGNC:11773 TGFBR2
KEGG Gene (Homo sapiens):7048 TGFBR2
Monarch:7048 TGFBR2
NCBI Gene:7048 TGFBR2
OMIM:190182 TGFBR2
UCSC:P37173 TGFBR2
Reference Transcript
RefSeq:NM_001024847.2 TGFBR2
RefSeq:NM_003242.5 TGFBR2
Other Identifiers
11724682_s_at
11750840_s_at
16938562
1814_at
1815_g_at
207334_PM_s_at
207334_s_at
208944_PM_at
208944_at
2615378
2615379
2615380
2615384
2615393
2615395
2615396
2615401
2615402
2615403
2615410
2615412
2615413
2615414
2615415
2615423
7048
8078350
A_14_P126005
A_23_P211957
D50683_at
GE57247
GE578892
GO:0000166
GO:0001568
GO:0001569
GO:0001570
GO:0001701
GO:0001837
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003180
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005026
GO:0005515
GO:0005524
GO:0005539
GO:0005576
GO:0005829
GO:0005886
GO:0005901
GO:0006468
GO:0006915
GO:0007155
GO:0007178
GO:0007179
GO:0007219
GO:0007224
GO:0007369
GO:0007420
GO:0007507
GO:0008284
GO:0009410
GO:0009893
GO:0009897
GO:0010468
GO:0010634
GO:0010718
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017002
GO:0019209
GO:0023052
GO:0030154
GO:0030324
GO:0032147
GO:0032924
GO:0034713
GO:0034714
GO:0035162
GO:0035909
GO:0036211
GO:0038023
GO:0042127
GO:0043011
GO:0043235
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048185
GO:0048701
GO:0048844
GO:0048856
GO:0048870
GO:0050431
GO:0051138
GO:0051216
GO:0051239
GO:0060021
GO:0060089
GO:0060090
GO:0060391
GO:0060395
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0061520
GO:0062009
GO:0070021
GO:0070723
GO:0071363
GO:0072091
GO:0098772
GO:0140096
GO:0141091
GO:1905007
GO:1905317
GO:1990086
GO:1990428
GO:2000379
GO:2000563
GO:2000736
HMNXSV003024864
ILMN_1726245
ILMN_1744862
ILMN_2384241
PH_hs_0004687
TC03000149.hg
TC03002268.hg
g1827474_3p_at
g4507468_3p_a_at
Participates
as an input of
TGFBR3 complex binds to TGFBR2 (Homo sapiens)
CBL binds TGFBR2 (Homo sapiens)
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
as a component of
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFBR2:CBL [plasma membrane] (Homo sapiens)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Homo sapiens)
TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
TGFBR2 Y470D [plasma membrane]
TGFBR2 E526Q [plasma membrane]
TGFBR2 D522N [plasma membrane]
TGFBR2 R528H [plasma membrane]
TGFBR2 R528C [plasma membrane]
TGFBR2 K128Afs*3 [cytosol]
TGFBR2 K128Sfs*35 [cytosol]
NEDD8-K556,K567-TGFBR2 [plasma membrane]
Inferred To
put [plasma membrane]
(Drosophila melanogaster)
TGFBR2 [plasma membrane]
(Bos taurus)
TGFBR2 [plasma membrane]
(Caenorhabditis elegans)
TGFBR2 [plasma membrane]
(Canis familiaris)
TGFBR2 [plasma membrane]
(Danio rerio)
TGFBR2 [plasma membrane]
(Gallus gallus)
TGFBR2 [plasma membrane]
(Mus musculus)
TGFBR2 [plasma membrane]
(Rattus norvegicus)
TGFBR2 [plasma membrane]
(Sus scrofa)
TGFBR2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003233.4
,
NP_001020018.1
ZINC - World Drugs
TGFR2_HUMAN
Guide to Pharmacology - Targets
1795
OpenTargets
ENSG00000163513
ZINC - FDA approved
TGFR2_HUMAN
ZINC - Substances
TGFR2_HUMAN
ZINC target
P37173
ZINC - Biogenic
TGFR2_HUMAN
PRO
P37173
PDB
4P7U
,
5TY4
,
1PLO
,
3KFD
,
5QIN
,
5TX4
,
5E92
,
4XJJ
,
5E91
,
5E8Y
,
1M9Z
,
7DV6
,
5E8V
,
2PJY
,
1KTZ
,
8YGZ
ZINC - Investigational
TGFR2_HUMAN
GeneCards
P37173
HPA
ENSG00000163513-TGFBR2
Ensembl
ENSG00000163513
,
ENSP00000295754
,
ENSP00000351905
,
ENST00000359013
,
ENST00000295754
Pharos - Targets
P37173
ZINC - Predictions - Purchasable
TGFR2_HUMAN
Orphanet
15611
HMDB Protein
HMDBP01237
Interactors (94)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.886
11
UniProt:P10600 TGFB3
3
TGFB3 [platelet alpha granule lumen]
(R-HSA-65942)
TGFB3(21-300) [extracellular region]
(R-HSA-2395290)
TGFB3 [extracellular region]
(R-HSA-114707)
0.765
8
UniProt:Q9H992 MARH7
0.643
5
UniProt:Q8IX30 SCUBE3
3
SCUBE3(?-993) [plasma membrane]
(R-HSA-8943967)
SCUBE3(21-?) [plasma membrane]
(R-HSA-8943978)
SCUBE3 [plasma membrane]
(R-HSA-8943884)
0.632
6
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:Q99435-2 NELL2
0.556
3
UniProt:Q969W3 VCF1
0.556
3
UniProt:Q3SY56 SP6
0.556
3
UniProt:Q8NCS7 SLC44A5
1
SLC44A5 [plasma membrane]
(R-HSA-444459)
0.556
3
UniProt:Q96BQ3 TRI43
0.556
3
UniProt:O14531 DPYSL4
3
p-Y-DPYSL4 [cytosol]
(R-HSA-399794)
DPYSL4 [cytosol]
(R-HSA-398126)
p-S544-DPYSL4 [cytosol]
(R-HSA-399808)
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9UMR2 DD19B
0.556
3
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.556
3
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.556
3
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q96NA2 RILP
1
RILP [lysosomal membrane]
(R-HSA-2213229)
0.556
3
UniProt:P26378-2 P263782
0.556
3
UniProt:Q9BZ95-3 Q9BZ953
0.556
3
UniProt:Q93084-2 Q930842
0.556
3
UniProt:P61966-2 AP1S1
0.556
3
UniProt:Q8NE08 Q8NE08
0.556
3
UniProt:Q4VBR4 Q4VBR4
0.556
3
UniProt:P61513 RPL37A
1
RPL37A [cytosol]
(R-HSA-72468)
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:O75874 IDH1
10
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
0.556
3
UniProt:P19544-6 WT1
0.556
3
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:P23276 KEL
1
KEL [plasma membrane]
(R-HSA-5694121)
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:Q8NC51 SERB1
0.556
3
UniProt:Q8TAT6 NPLOC4
2
NPLOC4 [nucleoplasm]
(R-HSA-5654987)
NPLOC4 [cytosol]
(R-HSA-9755492)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:O75143-2 O751432
0.556
3
UniProt:Q14728 MFS10
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:Q96IY1 NSL1
1
NSL1 [cytosol]
(R-HSA-375309)
0.556
3
UniProt:Q16549 PCSK7
0.556
3
UniProt:Q99720-4 SIGMAR1
0.556
3
UniProt:Q16586 SGCA
0.556
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.556
3
IntAct:EBI-25836632 CCSB
0.556
3
UniProt:Q7Z614-3 SNX20
0.556
3
UniProt:Q13428-5 TCOF1
0.556
3
UniProt:Q13702-2 Q137022
0.556
3
UniProt:Q8TBJ4 PLPPR1
1
LPPR1 [plasma membrane]
(R-HSA-6797625)
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:P51674 GPM6A
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8N448 LNX2
0.556
3
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.556
3
UniProt:O60259 KLK8
3
KLK8 propeptide [extracellular region]
(R-HSA-8850829)
proKLK8 [extracellular region]
(R-HSA-8850832)
KLK8 [extracellular region]
(R-HSA-8850833)
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:P54819 AK2
1
AK2 [mitochondrial intermembrane space]
(R-HSA-57822)
0.556
3
UniProt:Q9NUD9 PIGV
1
PIGV [endoplasmic reticulum membrane]
(R-HSA-162739)
0.556
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.556
3
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:Q96E93 KLRG1
1
KLRG1 [plasma membrane]
(R-HSA-198006)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.556
3
UniProt:P15036 ETS2
2
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
ETS2 [nucleoplasm]
(R-HSA-1629811)
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.556
3
UniProt:P36894 BMPR1A
2
BMPR1A [plasma membrane]
(R-HSA-201480)
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
0.527
4
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.527
3
UniProt:Q96S97 MYADM
0.527
4
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.527
3
UniProt:Q7Z4F1 LRP10
1
LRP10 [plasma membrane]
(R-HSA-2424275)
0.527
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.527
3
UniProt:Q9NZ56 FMN2
0.527
3
UniProt:Q8IWF6 DENND6A
1
DENND6A [cytosol]
(R-HSA-8876587)
0.527
3
UniProt:Q13705 ACVR2B
1
ACVR2B [plasma membrane]
(R-HSA-201656)
0.527
3
UniProt:Q9NRW1 RAB6B
6
RAB6B [endoplasmic reticulum membrane]
(R-HSA-8849252)
RAB6B [trans-Golgi network membrane]
(R-HSA-6810985)
RAB6B [Golgi membrane]
(R-HSA-8849249)
GGC-RAB6B [trans-Golgi network membrane]
(R-HSA-8876081)
GGC-RAB6B [cytosol]
(R-HSA-8874055)
RAB6B [cytosol]
(R-HSA-6810983)
0.527
2
UniProt:P55082 MFAP3
1
MFAP3 [extracellular region]
(R-HSA-2161382)
0.527
2
UniProt:Q969Z4 TR19L
0.527
2
UniProt:Q6P5Z2 PKN3
2
p-T718-PKN3 [cytosol]
(R-HSA-5623654)
PKN3 [cytosol]
(R-HSA-5623611)
0.527
3
UniProt:Q99741 CDC6
4
CDC6 [nucleoplasm]
(R-HSA-68542)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
p-CDC6 [cytosol]
(R-HSA-68583)
CDC6 [cytosol]
(R-HSA-113566)
0.527
2
UniProt:Q16513 PKN2
2
p-T816-PKN2 [cytosol]
(R-HSA-5623652)
PKN2 [cytosol]
(R-HSA-5623612)
0.527
3
UniProt:Q6PJF5 RHBDF2
2
iRHOM2 [Golgi lumen]
(R-HSA-9673787)
iRHOM2 [endoplasmic reticulum membrane]
(R-HSA-9662859)
0.527
2
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.527
3
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.527
3
UniProt:P07200
7
TGFB1 [platelet alpha granule lumen]
(R-SSC-65936)
TGFB1 [plasma membrane]
(R-SSC-5146781)
TGFB1 [Golgi lumen]
(R-SSC-114705)
TGFB1 [Golgi lumen]
(R-SSC-177108)
TGFB1 [Golgi lumen]
(R-SSC-9736812)
TGFB1 [extracellular region]
(R-SSC-2395367)
TGFB1 [extracellular region]
(R-SSC-170838)
0.525
2
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.524
3
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.508
2
UniProt:A2AGH6 Med12
2
Med12 [nucleoplasm]
(R-MMU-556777)
Med12 [nucleoplasm]
(R-MMU-212343)
0.471
3
UniProt:Q9BYF1 ACE2
5
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
0.463
2
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