NPC transports GCK1:GCKR from cytosol to nucleoplasm

Stable Identifier
R-HSA-170796
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Transport of glucokinase (GCK1):GCKR complex to the nucleus
ReviewStatus
5/5
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NPC transports GCK1:GCKR from cytosol to nucleoplasm
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The complex of glucokinase (GCK1) and glucokinase regulatory protein (GCKR) is translocated to the nucleus via the nuclear pore (Shiota et al. 1999).
Literature References
PubMed ID Title Journal Year
10601273 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

Shiota, C, Coffey, J, Grimsby, J, Grippo, JF, Magnuson, MA

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein import into nucleus (0006606)
Catalyst Activity

structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
structural constituent of nuclear pore (GO:0017056)
Orthologous Events
NPC transports GCK1:GCKR from cytosol to nucleoplasm (Canis familiaris)
NPC transports GCK1:GCKR from cytosol to nucleoplasm (Mus musculus)
NPC transports GCK1:GCKR from cytosol to nucleoplasm (Rattus norvegicus)
NPC transports GCK1:GCKR from cytosol to nucleoplasm (Xenopus tropicalis)
Reviewed
Hill, DP  (2025-08-28)
D'Eustachio, P  (2025-11-11)
Created
D'Eustachio, P  (2006-01-17)
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