Reactome | ADCY5 [plasma membrane]

ADCY5 [plasma membrane]

Stable Identifier

R-HSA-170684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase, type V, Adenylyl cyclase 5, ATP pyrophosphate-lyase 5

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
      - G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G alpha (s) activates adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Adenylate cyclase produces cAMP (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95622 ADCY5

Gene Names

ADCY5

Chain

chain:1-1261

Reference Genes

BioGPS Gene:111 ADCY5

COSMIC (genes):ADCY5 ADCY5

CTD Gene:111 ADCY5

dbSNP Gene:111 ADCY5

ENSEMBL:ENSG00000173175 ADCY5

HGNC:236 ADCY5

KEGG:hsa:111 ADCY5

Monarch:111 ADCY5

NCBI Gene:111 ADCY5

OMIM:600293 ADCY5

UCSC:O95622 ADCY5

Reference Transcript

Other Identifiers

111

11740037_a_at

16958201

228182_PM_at

228182_at

2692317

2692318

2692320

2692321

2692322

2692327

2692328

2692329

2692331

2692335

2692336

2692337

2692338

2692339

2692340

2692341

2692342

2692343

2692345

2692346

2692347

2692351

2692352

2692353

2692355

2692357

2692358

2692359

2692360

2692361

2692364

2692366

2692371

2692372

2692379

2692380

2692381

2692387

2692388

2692389

2692390

2692392

2692393

47579_at

59301_at

8090070

86617_at

A_23_P136623

A_24_P919249

GE85706

GO:0001973

GO:0003824

GO:0004016

GO:0005524

GO:0005886

GO:0005929

GO:0006171

GO:0007189

GO:0007191

GO:0007193

GO:0007195

GO:0007204

GO:0007626

GO:0008179

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0035556

GO:0042995

GO:0043226

GO:0046872

GO:0050877

GO:0050885

GO:0055086

GO:0061178

GO:0097110

GO:1901135

GO:1904322

HMNXSV003041728

Hs.9572.0.A1_3p_at

ILMN_1708588

PH_hs_0000985

PH_hs_0028553

TC03001710.hg

Participates

as a candidate of

as a member of

Adenylate cyclase [plasma membrane] (Homo sapiens)

Inferred To

CG12436 [plasma membrane] (Drosophila melanogaster)

ADCY5 [plasma membrane] (Bos taurus)

ADCY5 [plasma membrane] (Caenorhabditis elegans)

ADCY5 [plasma membrane] (Canis familiaris)

ADCY5 [plasma membrane] (Danio rerio)

ADCY5 [plasma membrane] (Dictyostelium discoideum)

ADCY5 [plasma membrane] (Gallus gallus)

ADCY5 [plasma membrane] (Mus musculus)

ADCY5 [plasma membrane] (Rattus norvegicus)

ADCY5 [plasma membrane] (Sus scrofa)

ADCY5 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001186571.1, NP_899200.1

Guide to Pharmacology - Targets

1282

ENSEMBL

ENSP00000419361, ENSG00000173175, ENST00000462833, ENST00000309879, ENSP00000308685

OpenTargets

ENSG00000173175

ZINC - Substances

ADCY5_HUMAN

ZINC target

O95622

PRO

O95622

GlyGen

O95622

PDB

8SL3, 8SL4

ZINC - Investigational

ADCY5_HUMAN

GeneCards

ADCY5

HPA

ENSG00000173175-ADCY5

Pharos - Targets

O95622

Orphanet

ADCY5

ZINC - Predictions - Purchasable

ADCY5_HUMAN

HMDB Protein

HMDBP00707

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