Dissociation of the Gi alpha:G olf complex

Stable Identifier
R-HSA-170674
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dissociation of the Gi alpha:G olf complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once the intrinsic GTPase hydrolyzes GTP to GDP, Galpha-i dissociates from adenylate cyclase, allowing it to re-associate with G-beta-gamma and starting a new cycle.

Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Dissociation of the Gi alpha:G olf complex (Bos taurus)
Dissociation of the Gi alpha:G olf complex (Caenorhabditis elegans)
Dissociation of the Gi alpha:G olf complex (Canis familiaris)
Dissociation of the Gi alpha:G olf complex (Danio rerio)
Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)
Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
Dissociation of the Gi alpha:G olf complex (Gallus gallus)
Dissociation of the Gi alpha:G olf complex (Mus musculus)
Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
Dissociation of the Gi alpha:G olf complex (Sus scrofa)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-01-10)
Cite Us!