Dissociation of the Gi alpha:G olf complex

Stable Identifier
R-HSA-170674
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
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Dissociation of the Gi alpha:G olf complex
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Once the intrinsic GTPase hydrolyzes GTP to GDP, Galpha-i dissociates from adenylate cyclase, allowing it to re-associate with G-beta-gamma and starting a new cycle.

Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
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Orthologous Events
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Dissociation of the Gi alpha:G olf complex (Canis familiaris)
Dissociation of the Gi alpha:G olf complex (Danio rerio)
Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)
Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
Dissociation of the Gi alpha:G olf complex (Gallus gallus)
Dissociation of the Gi alpha:G olf complex (Mus musculus)
Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
Dissociation of the Gi alpha:G olf complex (Sus scrofa)
Dissociation of the Gi alpha:G olf complex (Taeniopygia guttata)
Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-01-10)