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Dissociation of the Gi alpha:G olf complex
Stable Identifier
R-HSA-170674
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Adenylate cyclase inhibitory pathway (Homo sapiens)
Dissociation of the Gi alpha:G olf complex (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
Adenylate cyclase inhibitory pathway (Homo sapiens)
Dissociation of the Gi alpha:G olf complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once the intrinsic GTPase hydrolyzes GTP to GDP, Galpha-i dissociates from adenylate cyclase, allowing it to re-associate with G-beta-gamma and starting a new cycle.
Literature References
PubMed ID
Title
Journal
Year
7937899
Mechanism of GTP hydrolysis by G-protein alpha subunits
Kleuss, C
,
Gilman, AG
,
Sprang, SR
,
Raw, AS
,
Lee, E
Proc Natl Acad Sci U S A
1994
Participants
Input
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane]
(Homo sapiens)
Output
Adenylate cyclase (Mg2+ cofactor) [plasma membrane]
(Homo sapiens)
G alpha-olf:GDP complex [plasma membrane]
(Homo sapiens)
G-protein alpha (i):GDP [plasma membrane]
(Homo sapiens)
Participates
as an event of
Adenylate cyclase inhibitory pathway (Homo sapiens)
Orthologous Events
Dissociation of the Gi alpha:G olf complex (Bos taurus)
Dissociation of the Gi alpha:G olf complex (Caenorhabditis elegans)
Dissociation of the Gi alpha:G olf complex (Canis familiaris)
Dissociation of the Gi alpha:G olf complex (Danio rerio)
Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)
Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
Dissociation of the Gi alpha:G olf complex (Gallus gallus)
Dissociation of the Gi alpha:G olf complex (Mus musculus)
Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
Dissociation of the Gi alpha:G olf complex (Sus scrofa)
Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)
Authored
Jassal, B (2004-03-31)
Le Novere, N (2004-03-31)
Reviewed
Castagnoli, L (2008-11-06)
Created
Jassal, B (2006-01-10)
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