Galpha-olf:GTP binds to adenylate cyclase and activates it

Stable Identifier
R-HSA-170672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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G alpha-olf:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.

Literature References
PubMed ID Title Journal Year
8243272 Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system

Zigman, JM, Westermark, GT, LaMendola, J, Boel, E, Steiner, DF

Endocrinology 1993
11832410 Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells

R├ęgnauld, KL, Leteurtre, E, Gutkind, SJ, Gespach, CP, Emami, S

Am J Physiol Regul Integr Comp Physiol 2002
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
adenylate cyclase binding activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
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Created
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