Reactome | G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex

G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex

Stable Identifier

R-HSA-170671

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)

General

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G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex

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The chronic activation of mu-opioid receptors, which, when coupled to pertussis toxin-sensitive Galpha-i/o proteins, inhibit adenylyl cyclase (AC).

Literature References

PubMed ID	Title	Journal	Year
1658606	Multiple Gi protein subtypes regulate a single effector mechanism Gerhardt, MA, Neubig, RR	Mol Pharmacol	1991
9865521	The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells Francken, BJ, Jurzak, M, Vanhauwe, JF, Luyten, WH, Leysen, JE	Eur J Pharmacol	1998
17230639	Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3 Clark, MJ, Traynor, JR	J Neurochem	2006