G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex

Stable Identifier
R-HSA-170671
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The chronic activation of mu-opioid receptors, which, when coupled to pertussis toxin-sensitive Galpha-i/o proteins, inhibit adenylyl cyclase (AC).

Literature References
PubMed ID Title Journal Year
1658606 Multiple Gi protein subtypes regulate a single effector mechanism

Gerhardt, MA, Neubig, RR

Mol Pharmacol 1991
9865521 The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells

Francken, BJ, Jurzak, M, Vanhauwe, JF, Luyten, WH, Leysen, JE

Eur J Pharmacol 1998
17230639 Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3

Clark, MJ, Traynor, JR

J Neurochem 2006
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