Translocation of active Cdc25C to the nucleus

Stable Identifier
R-HSA-170149
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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During interphase, CDC25C, phosphorylated on serine residue 216, is associated with 14-3-3 proteins, preventing nuclear import. At the onset of mitosis, dephosphorylation of S216 of Cdc25C and dissociation of 14-3-3, with phosphorylation of CDC25C on S198 by activated PLK1 promotes nuclear import (Takizawa and Morgan 2000, Toyoshima-Morimoto et al. 2002, Bonnet et al. 2008). Activating CDC25C phosphorylation and nuclear translocation may further be enhanced by activated CCNB:CDK1 complexes (Bonnet et al. 2008).

Literature References
PubMed ID Title Journal Year
18384749 Differential phosphorylation of Cdc25C phosphatase in mitosis

Bonnet, J, Mayonove, P, Morris, MC

Biochem. Biophys. Res. Commun. 2008
11063929 Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C

Takizawa, CG, Morgan, DO

Curr Opin Cell Biol 2000
11897663 Plk1 promotes nuclear translocation of human Cdc25C during prophase

Toyoshima-Morimoto, F, Taniguchi, E, Nishida, E

EMBO Rep 2002
Participants
Participant Of
Orthologous Events
Created