Reactome | Translocation of active Cdc25C to the nucleus

Translocation of active Cdc25C to the nucleus

Stable Identifier

R-HSA-170149

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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Translocation of active Cdc25C to the nucleus

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During interphase, CDC25C, phosphorylated on serine residue 216, is associated with 14-3-3 proteins, preventing nuclear import. At the onset of mitosis, dephosphorylation of S216 of Cdc25C and dissociation of 14-3-3, with phosphorylation of CDC25C on S198 by activated PLK1 promotes nuclear import (Takizawa and Morgan 2000, Toyoshima-Morimoto et al. 2002, Bonnet et al. 2008). Activating CDC25C phosphorylation and nuclear translocation may further be enhanced by activated CCNB:CDK1 complexes (Bonnet et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11063929	Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C Takizawa, CG, Morgan, DO	Curr Opin Cell Biol	2000
18384749	Differential phosphorylation of Cdc25C phosphatase in mitosis Morris, MC, Bonnet, J, Mayonove, P	Biochem. Biophys. Res. Commun.	2008
11897663	Plk1 promotes nuclear translocation of human Cdc25C during prophase Toyoshima-Morimoto, F, Nishida, E, Taniguchi, E	EMBO Rep	2002