Translocation of active Cdc25C to the nucleus

Stable Identifier
Reaction [transition]
Homo sapiens
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During interphase, CDC25C, phosphorylated on serine residue 216, is associated with 14-3-3 proteins, preventing nuclear import. At the onset of mitosis, dephosphorylation of S216 of Cdc25C and dissociation of 14-3-3, with phosphorylation of CDC25C on S198 by activated PLK1 promotes nuclear import (Takizawa and Morgan 2000, Toyoshima-Morimoto et al. 2002, Bonnet et al. 2008). Activating CDC25C phosphorylation and nuclear translocation may further be enhanced by activated CCNB:CDK1 complexes (Bonnet et al. 2008).
Literature References
PubMed ID Title Journal Year
11063929 Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C

Takizawa, CG, Morgan, DO

Curr Opin Cell Biol 2000
18384749 Differential phosphorylation of Cdc25C phosphatase in mitosis

Morris, MC, Bonnet, J, Mayonove, P

Biochem. Biophys. Res. Commun. 2008
11897663 Plk1 promotes nuclear translocation of human Cdc25C during prophase

Toyoshima-Morimoto, F, Nishida, E, Taniguchi, E

EMBO Rep 2002
Orthologous Events
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