Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes

Stable Identifier
R-HSA-170131
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The rapid translocation of cyclin B1:Cdc2 from the cytoplasm to the nucleus at the onset of mitosis is a result of an increase in the rate of import and, likely, a decreased rate of export. The increased rate of nuclear import is dependent upon phosphorylation of the CRS which creates a nuclear import signal in the amino terminus of cyclin B1 (Hagting et al, 1999).

Literature References
PubMed ID Title Journal Year
10395539 Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

Hagting, A, Jackman, M, Simpson, K, Pines, J

Curr Biol 1999
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