Formation of Cyclin A:Cdc2 complexes

Stable Identifier
R-HSA-170084
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Formation of Cyclin A:Cdc2 complexes
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Cyclin A is synthesized and associates with Cdc2 in G1. Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active sites are blocked by a portion of the CDK molecule itself. Binding to their corresponding cyclin partner results in a conformational change that partially exposes the active site.
Literature References
PubMed ID Title Journal Year
9001210 The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.

Piwnica-Worms, H, Wu, Z, Liu, F, Stanton, JJ

Mol Cell Biol 1997
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Orthologous Events
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Created
Matthews, L  (2005-12-23)
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