Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site. The two B-type cyclins localize to different regions within the cell and and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).
Pines, J, Hunter, T
Hagting, A, Jackman, M, Simpson, K, Pines, J
Jackman, M, Firth, M, Pines, J
Draviam, VM, Orrechia, S, Lowe, M, Pardi, R, Pines, J
Bellanger, S, de Gramont, A, Sobczak-Thépot, J
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