Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).

Literature References
PubMed ID Title Journal Year
9670027 MPF localization is controlled by nuclear export

Pines, J, Hagting, A, Clute, P, Karlsson, C, Jackman, M

EMBO J 1998
10393926 Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

Takizawa, CG, Morgan, DO, Weis, K

Proc Natl Acad Sci U S A 1999
9679058 Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

Kornbluth, S, Powers, MA, Yang, J, Moore, JD, Brennan, J, Bardes, ES

Genes Dev 1998
Orthologous Events
Cite Us!