Reactome | UCP1 imports a proton

UCP1 imports a proton

Stable Identifier

R-HSA-170026

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Protons are translocated from the intermembrane space to the matrix

ReviewStatus

5/5

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Mitochondrial brown fat uncoupling protein 1 (UCP1, SLC25A7) transports a proton from the mitochondrial intermembrane space to the mitochondrial matrix, generating heat. The reaction does not occur without activation by fatty acids binding to the transporter (Zhao et al., 2017; reviewed by Li & Fromme, 2022). Phosphatidylethanolamines (PE), but not cardiolipins, in the membrane, are activating (Johnson et al., 2023), and purine nucleotides act as inhibitors (Kang & Chen, 2023). UCP1 can act as a monomer, but homodimer and -tetramer forms exist - we are showing the dimer here. UCP1 is mainly expressed in brown fat (Hoang et al., 2013; reviewed in Bertholet & Kirichok, 2022).

Literature References

PubMed ID	Title	Journal	Year
24196960	Expression, folding, and proton transport activity of human uncoupling protein-1 (UCP1) in lipid membranes: evidence for associated functional forms Hoang, T, Smith, MD, Jelokhani-Niaraki, M	J Biol Chem	2013
35269549	Uncoupling Protein 1 Does Not Produce Heat without Activation Fromme, T, Li, Y	Int J Mol Sci	2022
36827367	Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis Maschek, JA, Morgan, JT, Cox, JE, Panic, V, Rutter, J, Peterlin, AD, Villanueva, CJ, Lang, MJ, Balderas, E, Lodhi, IJ, Gerhart-Hines, Z, Funai, K, Jara-Ramos, A, Sustarsic, EG, Johnson, JM, Chaudhuri, D, Fisher-Wellman, KH, Sanchez, A	Sci Adv	2023
34758268	Mitochondrial H⁺ Leak and Thermogenesis Kirichok, Y, Bertholet, AM	Annu Rev Physiol	2022
37336486	Structural basis for the binding of DNP and purine nucleotides onto UCP1 Chen, L, Kang, Y	Nature	2023
28781081	Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid Wang, S, Wu, B, Liu, Z, OuYang, B, Zhu, Q, Zhao, L, Chou, JJ	Structure	2017