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Glycosylation of NA
Stable Identifier
R-HSA-169919
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Influenza Infection (Homo sapiens)
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Assembly of Viral Components at the Budding Site (Homo sapiens)
Glycosylation of NA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glycosylation of NA occurs within the endoplasmic reticulum and is believed to be neccessary for proper tetramerization of the NA dimers. Sugar residues become attached to four of the five potential glycosylation sites in the head of N1 neuraminidase (Hausman et al., 1997).
Literature References
PubMed ID
Title
Journal
Year
9400974
Biosynthesis, intracellular transport and enzymatic activity of an avian influenza A virus neuraminidase: role of unpaired cysteines and individual oligosaccharides
Klenk, HD
,
Garten, W
,
Hausmann, J
,
Kretzschmar, E
J Gen Virol
1997
Participants
Input
NA [endoplasmic reticulum membrane]
(Influenza A virus)
Output
Glycosylated NA [endoplasmic reticulum membrane]
(Influenza A virus)
Participates
as an event of
Assembly of Viral Components at the Budding Site (Homo sapiens)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
Gillespie, ME (2005-12-19)
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