Reactome | ITPR3 [endoplasmic reticulum membrane]

ITPR3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-169690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

IP3R3, IP3 receptor type 3

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
        
        IP3 receptor homotetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        IP3 receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
        
        AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14573 ITPR3

Gene Names

ITPR3

Chain

chain:1-2671

Reference Genes

BioGPS Gene:3710 ITPR3

COSMIC (genes):ITPR3 ITPR3

CTD Gene:3710 ITPR3

dbSNP Gene:3710 ITPR3

ENSEMBL:ENSG00000096433.11 ITPR3

HGNC:6182 ITPR3

KEGG Gene (Homo sapiens):3710 ITPR3

Monarch:3710 ITPR3

NCBI Gene:3710 ITPR3

OMIM:147267 ITPR3

UCSC:Q14573 ITPR3

Reference Transcript

RefSeq:NM_002224.3 ITPR3

Other Identifiers

11742963_at

11742964_a_at

17007543

182_at

201187_PM_s_at

201187_s_at

201188_PM_s_at

201188_s_at

201189_PM_s_at

201189_s_at

239542_PM_at

239542_at

2903783

2903784

2903785

2903795

2903801

2903803

2903804

2903805

2903806

2903807

2903809

2903810

2903811

2903812

2903813

2903814

2903815

2903816

2903817

2903818

2903819

2903820

2903821

2903823

2903825

2903826

2903827

2903829

2903830

2903831

2903832

2903833

2903835

2903836

2903838

2903839

2903842

2903844

2903845

2903846

2903847

2903848

2903849

2903851

2903852

2903853

2903854

2903855

2903857

2903858

2903859

2903860

2903862

2903863

2903864

2903865

2903868

2903871

2903872

2903875

2903877

2903881

2903882

2903883

3710

37343_at

8118734

A_14_P115289

A_14_P133907

A_23_P19517

GE58845

GE85666

GO:0000822

GO:0005215

GO:0005216

GO:0005220

GO:0005262

GO:0005509

GO:0005515

GO:0005634

GO:0005635

GO:0005640

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005903

GO:0006811

GO:0006816

GO:0007186

GO:0007204

GO:0007613

GO:0008289

GO:0012505

GO:0015085

GO:0015278

GO:0016020

GO:0016529

GO:0023052

GO:0030659

GO:0030667

GO:0031095

GO:0031410

GO:0035091

GO:0043025

GO:0043209

GO:0043226

GO:0043231

GO:0043235

GO:0043533

GO:0045177

GO:0048016

GO:0050877

GO:0050909

GO:0050913

GO:0050916

GO:0050917

GO:0051209

GO:0051592

GO:0055065

GO:0055085

GO:0060291

GO:0070588

GO:0070679

HMNXSV003038756

HMNXSV003040580

Hs.77515.0.A1_3p_a_at

ILMN_1815500

PH_hs_0004470

TC06000427.hg

U01062_at

g450470_3p_a_at

g4504794_3p_a_at

Participates

as a component of

as a member of

IP3 receptors [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ITPR3 [platelet dense tubular network membrane]

Inferred To

ITPR3 [endoplasmic reticulum membrane] (Bos taurus)

ITPR3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ITPR3 [endoplasmic reticulum membrane] (Canis familiaris)

ITPR3 [endoplasmic reticulum membrane] (Danio rerio)

ITPR3 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ITPR3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

ITPR3 [endoplasmic reticulum membrane] (Mus musculus)

ITPR3 [endoplasmic reticulum membrane] (Rattus norvegicus)

ITPR3 [endoplasmic reticulum membrane] (Sus scrofa)

itpr3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002215.2

Guide to Pharmacology - Targets

745

OpenTargets

ENSG00000096433

HPA

ENSG00000096433-ITPR3

GeneCards

Q14573

ZINC target

Q14573

Ensembl

ENST00000374316, ENSG00000096433, ENSP00000363435, ENST00000605930, ENSP00000475177

PRO

Q14573

Pharos - Targets

Q14573

HMDB Protein

HMDBP07746

PDB

7T3U, 7T3P, 6DQS, 6DQV, 7T3Q, 6DQJ, 6DR0, 6DRA, 6DQZ, 7T3R, 6DR2, 6DRC, 6DQN, 7T3T, 6UQK

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.64	12
UniProt:Q13507 TRPC3	1	TRPC3(1-848) [plasma membrane] (R-HSA-426172)	0.591	5

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