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MCM2-7 mediated fork unwinding
Stable Identifier
R-HSA-169468
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
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In budding yeast, all MCM proteins have been proved to be essential for elongation. The active form of this protein complex may be a heterohexamer. A subcomplex of MCM proteins consisting fo MCM4,6, and -7 has a weak helicase activity that may contribute to DNA unwinding.
Participants
Input
Replication Fork [nucleoplasm]
Output
Unwound fork [nucleoplasm]
Participates
as an event of
Unwinding of DNA (Homo sapiens)
Catalyst Activity
helicase activity of MCM2-7 [nucleoplasm]
Physical Entity
MCM2-7 [nucleoplasm]
(Homo sapiens)
Activity
helicase activity (GO:0004386)
Inferred From
Yeast Mcm2-7 mediated fork unwinding (Saccharomyces cerevisiae)
Authored
Tye, BK (2005-11-29)
Created
Gopinathrao, G (2005-11-29)
© 2025
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