Reactome | MCM2-7 mediated fork unwinding

MCM2-7 mediated fork unwinding

Stable Identifier

R-HSA-169468

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Unwinding of DNA (Homo sapiens)
        
        MCM2-7 mediated fork unwinding (Homo sapiens)

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In budding yeast, all MCM proteins have been proved to be essential for elongation. The active form of this protein complex may be a heterohexamer. A subcomplex of MCM proteins consisting fo MCM4,6, and -7 has a weak helicase activity that may contribute to DNA unwinding.

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