ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2

Stable Identifier
R-HSA-169270
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
Synonyms
Transfer of electrons from ETF to ubiquinone by ETF-QO
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ETF-ubiquinone oxidoreductase (ETFDH), catalyses the re-oxidation of reduced ETF, with ubiquinone (CoQ) as the electron acceptor being reduced to ubiquinol (QH2) (Estornell et al. 1992, MacLennan et al. 1997).
Literature References
PubMed ID Title Journal Year
4288886 Studies on the mechanisms of oxidative phosphorylation. IX. Effect of cytochrome c on energy-linked processes

MacLennan, DH, Lenaz, G, Szarkowska, L

J. Biol. Chem. 1966
1327877 Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

Estornell, E, Fato, R, Castelluccio, C, Cavazzoni, M, Parenti Castelli, G, Lenaz, G

FEBS Lett. 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

electron-transferring-flavoprotein dehydrogenase activity of ETFDH [mitochondrial inner membrane]

Physical Entity
ETFDH [mitochondrial inner membrane] (Homo sapiens)
Activity
electron-transferring-flavoprotein dehydrogenase activity (GO:0004174)
Orthologous Events
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Caenorhabditis elegans)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Canis familiaris)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Danio rerio)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Dictyostelium discoideum)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Drosophila melanogaster)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Mus musculus)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Rattus norvegicus)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Saccharomyces cerevisiae)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Schizosaccharomyces pombe)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Sus scrofa)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Xenopus tropicalis)
Cross References
RHEA
Reviewed
Hill, DP  (2024-05-16)
Created
Jassal, B  (2005-11-25)
Cite Us!