ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2

Stable Identifier
R-HSA-169270
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
Synonyms
Transfer of electrons from ETF to ubiquinone by ETF-QO
ReviewStatus
5/5
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ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2
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ETF-ubiquinone oxidoreductase (ETFDH), catalyses the re-oxidation of reduced ETF, with ubiquinone (CoQ) as the electron acceptor being reduced to ubiquinol (QH2) (Estornell et al. 1992, MacLennan et al. 1997).

Literature References
PubMed ID Title Journal Year
4288886 Studies on the mechanims of oxidative phosphorylation. IX. Effect of cytochrome c on energy-linked processes

Szarkowska, L, Lenaz, G, MacLennan, DH

J. Biol. Chem. 1966
1327877 Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

Cavazzoni, M, Parenti Castelli, G, Estornell, E, Lenaz, G, Fato, R, Castelluccio, C

FEBS Lett. 1992
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Output
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Catalyst Activity

electron-transferring-flavoprotein dehydrogenase activity of ETFDH [mitochondrial matrix]

Physical Entity
ETFDH [mitochondrial matrix] (Homo sapiens)
Activity
electron-transferring-flavoprotein dehydrogenase activity (GO:0004174)
Orthologous Events
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Caenorhabditis elegans)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Dictyostelium discoideum)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Saccharomyces cerevisiae)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Sus scrofa)
ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Xenopus tropicalis)
Created
Jassal, B  (2005-11-25)
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