TLR1:TLR2 is recruited to ligand:CD14

Stable Identifier
R-HSA-168951
Type
Reaction
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane
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TLR1:TLR2 is recruited to ligand:CD14
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The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others.

Literature References
PubMed ID Title Journal Year
10426996 Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

Zychlinsky, A, Klimpel, GR, Devaux, B, Yang, RB, Radolf, JD, Mark, MR, Suggett, S, Godowski, P, Aliprantis, AO

Science 1999
15241424 Inferences, questions and possibilities in Toll-like receptor signalling

Beutler, B

Nature 2004
16455995 Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling

Wetzler, LM, King, CA, Gunawardana, J, Golenbock, DT, Halmen, KA, Massari, P, Visintin, A

J Immunol 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
Authored
Zwaginga, JJ  (2006-04-19)
D'Eustachio, P  (2006-04-19)
Gay, NJ  (2006-04-19)
Gale M, Jr  (2006-04-19)
Reviewed
Gillespie, ME  (2010-11-30)
D'Eustachio, P  (2006-07-03)
Created
de Bono, B  (2005-11-22)
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