MAVS interacts with RIPK1 and FADD

Stable Identifier
R-HSA-168934
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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MAVS interacts with RIPK1 and FADD
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Receptor-interacting protein 1 (RIP1) and Fas-Associated Death Domain (FADD) are death domain (DD)-containing proteins. These proteins interact with IPS-1 and activate NF-kB through interaction and activation of caspase-8 and caspase-10.

Literature References
PubMed ID Title Journal Year
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Takeuchi, O, Ishii, KJ, Kumar, H, Sato, S, Kawai, T, Takahashi, K, Kato, H, Coban, C

Nat Immunol 2005
Participants
Input
Output
Participates
as an event of
Orthologous Events
IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
de Bono, B  (2005-11-22)
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