MAVS interacts with RIPK1 and FADD

Stable Identifier
R-HSA-168934
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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MAVS interacts with RIPK1 and FADD
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Receptor-interacting protein 1 (RIP1) and Fas-Associated Death Domain (FADD) are death domain (DD)-containing proteins. These proteins interact with IPS-1 and activate NF-kB through interaction and activation of caspase-8 and caspase-10.

Literature References
PubMed ID Title Journal Year
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar, H, Kato, H, Ishii, KJ, Takeuchi, O

Nat Immunol 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
de Bono, B  (2005-11-22)