Viral dsRNA:TLR3 recruits TRIF (TICAM1)

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TIR-domain-containing adaptor inducing interferon-beta (TRIF or TICAM1) was shown to play an essential role in TLR3 signaling. All poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF-/- mice [Yamamoto et al. 2003].

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H

Science 2003
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Latz, E, Barnes, BJ, Golenbock, DT, Pitha-Rowe, PM, Monks, BG, Caffrey, DR, Visintin, A

J Exp Med 2003
12539043 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T

Nat Immunol 2003
Orthologous Events
Cite Us!