NS1 binds PKR

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
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Influenza virus inhibits the host double-stranded-RNA-activated protein kinase (PKR) in several steps. First, PKR binds the viral non-structural protein NS1, an interaction in which the NS1 N terminus is critical. This interaction inhibits PKR dimerization and autophosphorylation, resulting in sustained general protein translation despite the presence of dsRNA. The inhibition of PKR is an indispensable contribution of NS1 to the viral life cycle (Tan & Katze, 1998; Hatada et al, 1999; Bergmann et al, 2000; Li et al, 2006; Dauber et al, 2006; Schierhorn et al, 2017).

Literature References
PubMed ID Title Journal Year
16466763 Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

Sen, GC, Krug, RM, Min, JY, Li, S

Virology 2006
16987984 Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon

Schneider, J, Dauber, B, Wolff, T

J Virol 2006
28250123 Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR

Pleschka, S, Jolmes, F, Budt, M, Herold, S, Herrmann, A, Peteranderl, C, Mielke, M, Bespalowa, J, Wolff, T, Schierhorn, KL, Saenger, S, Dzieciolowski, J

J Virol 2017
10846107 Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication

Bergmann, M, Pehamberger, H, Carnero, E, Wolff, K, Muster, T, Garcia-Sastre, A, Palese, P

J. Virol. 2000
9971827 Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells

Saito, S, Fukuda, R, Hatada, E

J Virol 1999
9781815 Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase

Tan, SL, Katze, MG

J Interferon Cytokine Res 1998
Event Information
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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