Binding of NS1 to poly(A)-binding protein II (PABII)

Stable Identifier
R-HSA-168883
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Binding of NS1 to poly(A)-binding protein II (PABII)
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The influenza virus non-structural protein 1 (NS1) binds to the host cell's poly(A)-binding protein II (PABII) thus preventing PABII from properly extending the poly-A tail of pre-mRNA within the host cell nucleus. These pre-mRNAs are then prevented from exiting the nucleus.
Literature References
PubMed ID Title Journal Year
10205180 Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery

Chen, Z, Li, Y, Krug, RM

EMBO J 1999
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
symbiont-mediated suppression of host mRNA processing (0039524)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
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