PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis

Stable Identifier
R-HSA-168878
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space
ReviewStatus
5/5
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PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis
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Influenza A virus induces apoptosis in a variety of ways including binding of viral PB1-F2 to host mitochondrial adenine nucleotide translocator 3 (ANT3).
Literature References
PubMed ID Title Journal Year
15163724 PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes

Henklein, P, Basanez, G, Yewdell, JW, Chanturiya, AN, Zimmerberg, J, Schubert, U

J Virol 2004
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
induction by virus of host immune response (0046730)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2013-11-18)
Reviewed
Gale M, Jr  (2004-05-12)
Created
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